Malaria Research Challenges in Low Prevalence Settings

Overview

Journal Malar J

Publisher Biomed Central

Specialty Tropical Medicine

Date 2012 Oct 27

PMID 23098277

Citations 23

Authors

Gillian Stresman

Tamaki Kobayashi

Aniset Kamanga

Philip E Thuma

Sungano Mharakurwa

William J Moss

Clive Shiff

Affiliations

Soon will be listed here.

Abstract

The prevalence of malaria has reduced significantly in some areas over the past decade. These reductions have made local elimination possible and the research agenda has shifted to this new priority. However, there are critical issues that arise when studying malaria in low transmission settings, particularly identifying asymptomatic infections, accurate detection of individuals with microparasitaemic infections, and achieving a sufficient sample size to have an adequately powered study. These challenges could adversely impact the study of malaria elimination if they remain unanswered.

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References

Greenwood B . The microepidemiology of malaria and its importance to malaria control. Trans R Soc Trop Med Hyg. 1989; 83 Suppl:25-9. DOI: 10.1016/0035-9203(89)90599-3. View

Gething P, Patil A, Smith D, Guerra C, Elyazar I, Johnston G . A new world malaria map: Plasmodium falciparum endemicity in 2010. Malar J. 2011; 10:378. PMC: 3274487. DOI: 10.1186/1475-2875-10-378. View

Coleman R, Kumpitak C, Ponlawat A, Maneechai N, Phunkitchar V, Rachapaew N . Infectivity of asymptomatic Plasmodium-infected human populations to Anopheles dirus mosquitoes in western Thailand. J Med Entomol. 2004; 41(2):201-8. DOI: 10.1603/0022-2585-41.2.201. View

Sutcliffe C, Kobayashi T, Hamapumbu H, Shields T, Mharakurwa S, Thuma P . Reduced risk of malaria parasitemia following household screening and treatment: a cross-sectional and longitudinal cohort study. PLoS One. 2012; 7(2):e31396. PMC: 3272029. DOI: 10.1371/journal.pone.0031396. View

McMorrow M, Aidoo M, Kachur S . Malaria rapid diagnostic tests in elimination settings--can they find the last parasite?. Clin Microbiol Infect. 2011; 17(11):1624-31. PMC: 4821879. DOI: 10.1111/j.1469-0691.2011.03639.x. View

Mahajan B, Zheng H, Pham P, Sedegah M, Majam V, Akolkar N . Polymerase chain reaction-based tests for pan-species and species-specific detection of human Plasmodium parasites. Transfusion. 2012; 52(9):1949-56. DOI: 10.1111/j.1537-2995.2011.03541.x. View

Bousema T, Drakeley C . Epidemiology and infectivity of Plasmodium falciparum and Plasmodium vivax gametocytes in relation to malaria control and elimination. Clin Microbiol Rev. 2011; 24(2):377-410. PMC: 3122489. DOI: 10.1128/CMR.00051-10. View

Shekalaghe S, Drakeley C, van den Bosch S, ter Braak R, van den Bijllaardt W, Mwanziva C . A cluster-randomized trial of mass drug administration with a gametocytocidal drug combination to interrupt malaria transmission in a low endemic area in Tanzania. Malar J. 2011; 10:247. PMC: 3169516. DOI: 10.1186/1475-2875-10-247. View

Schachterle S, Mtove G, Levens J, Clemens E, Shi L, Raj A . Prevalence and density-related concordance of three diagnostic tests for malaria in a region of Tanzania with hypoendemic malaria. J Clin Microbiol. 2011; 49(11):3885-91. PMC: 3209109. DOI: 10.1128/JCM.01157-11. View

10.

Price R, Nosten F, Luxemburger C, Ter Kuile F, Paiphun L, CHONGSUPHAJAISIDDHI T . Effects of artemisinin derivatives on malaria transmissibility. Lancet. 1996; 347(9016):1654-8. DOI: 10.1016/s0140-6736(96)91488-9. View

11.

Bousema T, Griffin J, Sauerwein R, Smith D, Churcher T, Takken W . Hitting hotspots: spatial targeting of malaria for control and elimination. PLoS Med. 2012; 9(1):e1001165. PMC: 3269430. DOI: 10.1371/journal.pmed.1001165. View

12.

Manjurano A, Okell L, Lukindo T, Reyburn H, Olomi R, Roper C . Association of sub-microscopic malaria parasite carriage with transmission intensity in north-eastern Tanzania. Malar J. 2011; 10:370. PMC: 3276450. DOI: 10.1186/1475-2875-10-370. View

13.

Stresman G, Kamanga A, Moono P, Hamapumbu H, Mharakurwa S, Kobayashi T . A method of active case detection to target reservoirs of asymptomatic malaria and gametocyte carriers in a rural area in Southern Province, Zambia. Malar J. 2010; 9:265. PMC: 2959066. DOI: 10.1186/1475-2875-9-265. View

14.

Karl S, Gurarie D, Zimmerman P, King C, Pierre T, Davis T . A sub-microscopic gametocyte reservoir can sustain malaria transmission. PLoS One. 2011; 6(6):e20805. PMC: 3114851. DOI: 10.1371/journal.pone.0020805. View

15.

Lindsay S, Snow R, Broomfield G, Janneh M, Wirtz R, Greenwood B . Impact of permethrin-treated bednets on malaria transmission by the Anopheles gambiae complex in The Gambia. Med Vet Entomol. 1989; 3(3):263-71. DOI: 10.1111/j.1365-2915.1989.tb00226.x. View

16.

Shiff C . Integrated approach to malaria control. Clin Microbiol Rev. 2002; 15(2):278-93. PMC: 118067. DOI: 10.1128/CMR.15.2.278-293.2002. View

17.

Smith D, Dushoff J, Snow R, Hay S . The entomological inoculation rate and Plasmodium falciparum infection in African children. Nature. 2005; 438(7067):492-5. PMC: 3128496. DOI: 10.1038/nature04024. View

18.

Kitua A, Ogundahunsi O, Lines J, Mgone C . Conquering malaria: enhancing the impact of effective interventions towards elimination in the diverse and changing epidemiology. J Glob Infect Dis. 2011; 3(2):161-5. PMC: 3125030. DOI: 10.4103/0974-777X.81694. View

19.

Hay S, Guerra C, Tatem A, Noor A, Snow R . The global distribution and population at risk of malaria: past, present, and future. Lancet Infect Dis. 2004; 4(6):327-36. PMC: 3145123. DOI: 10.1016/S1473-3099(04)01043-6. View

20.

. A research agenda for malaria eradication: diagnoses and diagnostics. PLoS Med. 2011; 8(1):e1000396. PMC: 3026696. DOI: 10.1371/journal.pmed.1000396. View