The Role of HLA in Cord Blood Transplantation

Overview

Journal Bone Marrow Res

Date 2012 Oct 26

PMID 23097706

Citations 4

Authors

Catherine Stavropoulos-Giokas

Amalia Dinou

Andreas Papassavas

Affiliations

Soon will be listed here.

Abstract

In recent years, umbilical cord blood (CB), a rich source of hematopoietic stem cells (HSC), has been used successfully as an alternative HSC source to treat a variety of hematologic, immunologic, genetic, and oncologic disorders. CB has several advantages, including prompt availability of the transplant, decrease of graft versus host disease (GVHD) and better long-term immune recovery, resulting in a similar long-term survival. Studies have shown that some degree of HLA mismatches is acceptable. This review is intended to outline the main aspects of HLA matching in different settings (related, pediatric, adult, or double-unit HSCT), its effect on transplantation outcome and the role of HLA in donor selection.

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