Novel Developments in the Mechanisms of Immune Tolerance to Allergens

Overview

Journal Hum Vaccin Immunother

Specialty Allergy & Immunology

Date 2012 Oct 26

PMID 23095863

Citations 3

Authors

Thomas Eiwegger

Saskia Gruber

Zsolt Szepfalusi

Cezmi A Akdis

Affiliations

Soon will be listed here.

Abstract

Allergy is the result of a disbalanced immune response to environmental innocuous antigens. Despite of accumulating data to define the pathomechanisms that take place in case of allergic diseases a detailed understanding of sequence of events that lead to the "normal" scenario of tolerance development are still under debate. Allergen-specific immunotherapy is the only causal treatment of allergic diseases. It modifies the immune response to a particular antigen to achieve tolerance against the symptom-causing allergen. This process is considered to mirror physiological peripheral tolerance induction. A number of immunological changes have been described to occur under allergen immunotherapy, including the generation of allergen-specific regulatory T cells, the induction of allergen-specific IgG4, an increase in the Th1/Th2 cytokine ratio and decreased activation and function of effector cells such as mast cells, basophils and eosinophils.

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