Community Outbreak of Adenovirus, Taiwan, 2011

Overview

Journal Emerg Infect Dis

Specialty Infectious Diseases

Date 2012 Oct 25

PMID 23092602

Citations 43

Authors

Tsung-Pei Tsou

Boon-Fatt Tan

Hsin-Yu Chang

Wan-Chin Chen

Yuan-Pin Huang

Chen-Yin Lai

Yen-Nan Chao

Sung-Hsi Wei

Min-Nan Hung

Li-Ching Hsu

Chun-Yi Lu

Pei-Lan Shao

Jung-Jung Mu

Luan-Yin Chang

Ming-Tsan Liu

Li-Min Huang

Affiliations

Soon will be listed here.

Abstract

In 2011, a large community outbreak of human adenovirus (HAdV) in Taiwan was detected by a nationwide surveillance system. The epidemic lasted from week 11 through week 41 of 2011 (March 14-October 16, 2011). Although HAdV-3 was the predominant strain detected (74%), an abrupt increase in the percentage of infections caused by HAdV-7 occurred, from 0.3% in 2008-2010 to 10% in 2011. Clinical information was collected for 202 inpatients infected with HAdV; 31 (15.2%) had severe infection that required intensive care, and 7 of those patients died. HAdV-7 accounted for 10%, 12%, and 41% of infections among outpatients, inpatients with nonsevere infection, and inpatients with severe infection, respectively (p<0.01). The HAdV-7 strain detected in this outbreak is identical to a strain recently reported in the People's Republic of China (HAdV7-HZ/SHX/CHN/2009). Absence of circulating HAdV-7 in previous years and introduction of an emerging strain are 2 factors that caused this outbreak.

Citing Articles

Exploring the Efficacy of Peptides and Mimics against Influenza A Virus, Adenovirus, and Murine Norovirus.

Urmi U, Vijay A, Willcox M, Attard S, Enninful G, Kumar N Int J Mol Sci. 2024; 25(13).

PMID: 39000138 PMC: 11240954. DOI: 10.3390/ijms25137030.

Adenovirus and co-infection as a risk factor for severe community-acquired pneumonia in children.

Chen Q, Lin L, Zhang N, Yang Y Front Pediatr. 2024; 12:1337786.

PMID: 38357505 PMC: 10864498. DOI: 10.3389/fped.2024.1337786.

Identification of Large Adenovirus Infection Outbreak at University by Multipathogen Testing, South Carolina, USA, 2022.

Tori M, Chontos-Komorowski J, Stacy J, Lamson D, St George K, Lail A Emerg Infect Dis. 2024; 30(2):358-362.

PMID: 38270142 PMC: 10826757. DOI: 10.3201/eid3002.230623.

Seroprevalence of neutralizing antibodies to human mastadenovirus serotypes 3 and 7 in healthy children from guangdong province.

Kuang L, Wang C, Chen H, Li Y, Liang Z, Xu T Heliyon. 2023; 9(6):e16986.

PMID: 37346335 PMC: 10279900. DOI: 10.1016/j.heliyon.2023.e16986.

Human adenovirus type 7 subunit vaccine induces dendritic cell maturation through the TLR4/NF-κB pathway is highly immunogenic.

Li Y, Yang X, Zhao R, Xiu Z, Li S, Li Y Front Cell Infect Microbiol. 2023; 13:1117230.

PMID: 37124037 PMC: 10130362. DOI: 10.3389/fcimb.2023.1117230.

References

Choi E, Lee H, Kim S, Eun B, Kim N, Lee J . Ten-year analysis of adenovirus type 7 molecular epidemiology in Korea, 1995-2004: implication of fiber diversity. J Clin Virol. 2006; 35(4):388-93. DOI: 10.1016/j.jcv.2006.01.001. View

Tang L, Wang L, Tan X, Xu W . Adenovirus serotype 7 associated with a severe lower respiratory tract disease outbreak in infants in Shaanxi Province, China. Virol J. 2011; 8:23. PMC: 3030507. DOI: 10.1186/1743-422X-8-23. View

Cheng C, Huang L, Kao C, Lee P, Chen J, Lu C . Molecular and clinical characteristics of adenoviral infections in Taiwanese children in 2004-2005. Eur J Pediatr. 2007; 167(6):633-40. DOI: 10.1007/s00431-007-0562-4. View

Noda M, Yoshida T, Sakaguchi T, Ikeda Y, Yamaoka K, Ogino T . Molecular and epidemiological analyses of human adenovirus type 7 strains isolated from the 1995 nationwide outbreak in Japan. J Clin Microbiol. 2002; 40(1):140-5. PMC: 120110. DOI: 10.1128/JCM.40.1.140-145.2002. View

Aberle S, Aberle J, Steininger C, Matthes-Martin S, Pracher E, Popow-Kraupp T . Adenovirus DNA in serum of children hospitalized due to an acute respiratory adenovirus infection. J Infect Dis. 2003; 187(2):311-4. DOI: 10.1086/367808. View

Kaneko H, Suzutani T, Aoki K, Kitaichi N, Ishida S, Ishiko H . Epidemiological and virological features of epidemic keratoconjunctivitis due to new human adenovirus type 54 in Japan. Br J Ophthalmol. 2010; 95(1):32-6. DOI: 10.1136/bjo.2009.178772. View

Ryan M, Gray G, Smith B, McKeehan J, Hawksworth A, Malasig M . Large epidemic of respiratory illness due to adenovirus types 7 and 3 in healthy young adults. Clin Infect Dis. 2002; 34(5):577-82. DOI: 10.1086/338471. View

Lin K, Lin Y, Chen H, Ke G, Chiang C, Hwang K . A two decade survey of respiratory adenovirus in Taiwan: the reemergence of adenovirus types 7 and 4. J Med Virol. 2004; 73(2):274-9. DOI: 10.1002/jmv.20087. View

Erdman D, Xu W, Gerber S, Gray G, Schnurr D, Kajon A . Molecular epidemiology of adenovirus type 7 in the United States, 1966-2000. Emerg Infect Dis. 2002; 8(3):269-77. PMC: 2732469. DOI: 10.3201/eid0803.010190. View

10.

Gerber S, Erdman D, Pur S, Diaz P, Segreti J, Kajon A . Outbreak of adenovirus genome type 7d2 infection in a pediatric chronic-care facility and tertiary-care hospital. Clin Infect Dis. 2001; 32(5):694-700. DOI: 10.1086/319210. View

11.

Emovon O, Lin A, Howell D, Afzal F, Baillie M, Rogers J . Refractory adenovirus infection after simultaneous kidney-pancreas transplantation: successful treatment with intravenous ribavirin and pooled human intravenous immunoglobulin. Nephrol Dial Transplant. 2003; 18(11):2436-8. DOI: 10.1093/ndt/gfg365. View

12.

Pavia A . Viral infections of the lower respiratory tract: old viruses, new viruses, and the role of diagnosis. Clin Infect Dis. 2011; 52 Suppl 4:S284-9. PMC: 3106235. DOI: 10.1093/cid/cir043. View

13.

Tamura K, Dudley J, Nei M, Kumar S . MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Mol Biol Evol. 2007; 24(8):1596-9. DOI: 10.1093/molbev/msm092. View

14.

Lee J, Choi E, Lee H . Clinical severity of respiratory adenoviral infection by serotypes in Korean children over 17 consecutive years (1991-2007). J Clin Virol. 2010; 49(2):115-20. DOI: 10.1016/j.jcv.2010.07.007. View

15.

Paduch D . Viral lower urinary tract infections. Curr Urol Rep. 2008; 8(4):324-35. PMC: 7089127. DOI: 10.1007/s11934-007-0080-y. View

16.

Selvaraju S, Kovac M, Dickson L, Kajon A, Selvarangan R . Molecular epidemiology and clinical presentation of human adenovirus infections in Kansas City children. J Clin Virol. 2011; 51(2):126-31. DOI: 10.1016/j.jcv.2011.02.014. View

17.

Hong J, Lee H, Piedra P, Choi E, Park K, Koh Y . Lower respiratory tract infections due to adenovirus in hospitalized Korean children: epidemiology, clinical features, and prognosis. Clin Infect Dis. 2001; 32(10):1423-9. DOI: 10.1086/320146. View

18.

Lankester A, Heemskerk B, Claas E, Schilham M, Beersma M, Bredius R . Effect of ribavirin on the plasma viral DNA load in patients with disseminating adenovirus infection. Clin Infect Dis. 2004; 38(11):1521-5. DOI: 10.1086/420817. View

19.

Megged O, Erlichman M, Kleid D, Wolf D, Schlesinger Y . Hyponatremia associated with adenovirus infection in twin infants. Eur J Pediatr. 2006; 165(12):907-8. DOI: 10.1007/s00431-006-0195-z. View

20.

Kim Y, Hong J, Lee H, Shin S, Kim Y, Inada T . Genome type analysis of adenovirus types 3 and 7 isolated during successive outbreaks of lower respiratory tract infections in children. J Clin Microbiol. 2003; 41(10):4594-9. PMC: 254340. DOI: 10.1128/JCM.41.10.4594-4599.2003. View