Seroprevalence of Antibodies Against Chikungunya, Dengue, and Rift Valley Fever Viruses After Febrile Illness Outbreak, Madagascar

Overview

Journal Emerg Infect Dis

Specialty Infectious Diseases

Date 2012 Oct 25

PMID 23092548

Citations 29

Authors

Norbert G Schwarz

Mirko Girmann

Njary Randriamampionona

Alexandra Bialonski

Deborah Maus

Anne Caroline Krefis

Christine Njarasoa

Jeanne Fleury Rajanalison

Herly Daniel Ramandrisoa

Maurice Lucien Randriarison

Jurgen May

Jonas Schmidt-Chanasit

Raphael Rakotozandrindrainy

Affiliations

Soon will be listed here.

Abstract

In October 2009, two-3 months after an outbreak of a febrile disease with joint pain on the eastern coast of Madagascar, we assessed serologic markers for chikungunya virus (CHIKV), dengue virus (DENV), and Rift Valley fever virus (RVFV) in 1,244 pregnant women at 6 locations. In 2 eastern coast towns, IgG seroprevalence against CHIKV was 45% and 23%; IgM seroprevalence was 28% and 5%. IgG seroprevalence against DENV was 17% and 11%. No anti-DENV IgM was detected. At 4 locations, 450-1,300 m high, IgG seroprevalence against CHIKV was 0%-3%, suggesting CHIKV had not spread to higher inland-altitudes. Four women had IgG against RVFV, probably antibodies from a 2008 epidemic. Most (78%) women from coastal locations with CHIKV-specific IgG reported joint pain and stiffness; 21% reported no symptoms. CHIKV infection was significantly associated with high bodyweight. The outbreak was an isolated CHIKV epidemic without relevant DENV co-transmission.

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