Population-based Study of High Plasma C-reactive Protein Concentrations Among the Inuit of Nunavik

Overview

Journal Int J Circumpolar Health

Date 2012 Oct 23

PMID 23087913

Citations 8

Authors

Marie-Eve Labonte

Eric Dewailly

Marie-Ludivine Chateau-Degat

Patrick Couture

Benoit Lamarche

Affiliations

Soon will be listed here.

Abstract

Background: The shift away from traditional lifestyle in the Inuit population over the past few decades has been associated with an increased prevalence of coronary heart disease (CHD) risk factors such as obesity, high blood pressure (BP) and diabetes. However, the impact of this transition on the pro-inflammatory marker high-sensitivity C-reactive protein (hs-CRP) has not been documented.

Objectives: To examine the prevalence of elevated plasma hs-CRP concentrations in Inuit from Nunavik in the province of Quebec (Canada) and identify anthropometric, biochemical and lifestyle risk factors associated with elevated hs-CRP.

Design: A population-representative sample of 801 Inuit residents from 14 villages of Nunavik, aged between 18 and 74 years, was included in the analyses. Subjects participated in a clinical session and completed questionnaires on lifestyle. Multivariate logistic regression was used to determine risk factors for elevated hs-CRP.

Results: Elevated plasma hs-CRP concentrations (≥ 2 mg/L) were present in 32.7% (95% confidence interval (CI) 29.5-35.8) of the Inuit adult population and were more prevalent among women than among men (36.7% vs. 29.0%, p=0.007). Multivariate logistic regression analysis indicated that every 1 mmHg increase in systolic BP was associated with a 3% increase in the odds of having hs-CRP concentrations ≥ 2 mg/L in the Inuit population (95% CI 1.01-1.04). The combination of older age (≥ 50 vs. <30 years) and elevated waist circumference (gender-specific cut-off values) in a multivariate logistic model was also associated with a 13.3-fold increase in the odds of having plasma hs-CRP concentrations ≥ 2 mg/L (95% CI 5.8-30.9).

Conclusions: These data indicate that elevated hs-CRP is relatively prevalent among Inuit with values that are similar to those seen in Canadian Caucasian populations. Sex, age, waist circumference and systolic BP are major factors that increase the risk of this inflammatory phenotype among Inuit from Nunavik, despite their different lifestyle background compared with Caucasians.

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References

Pirro M, Bergeron J, Dagenais G, BERNARD P, Cantin B, Despres J . Age and duration of follow-up as modulators of the risk for ischemic heart disease associated with high plasma C-reactive protein levels in men. Arch Intern Med. 2001; 161(20):2474-80. DOI: 10.1001/archinte.161.20.2474. View

Sharma S . Assessing diet and lifestyle in the Canadian Arctic Inuit and Inuvialuit to inform a nutrition and physical activity intervention programme. J Hum Nutr Diet. 2010; 23 Suppl 1:5-17. DOI: 10.1111/j.1365-277X.2010.01093.x. View

Ridker P . Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation. 2003; 107(3):363-9. DOI: 10.1161/01.cir.0000053730.47739.3c. View

Alberti K, Zimmet P, Shaw J . The metabolic syndrome--a new worldwide definition. Lancet. 2005; 366(9491):1059-62. DOI: 10.1016/S0140-6736(05)67402-8. View

Han Y, Runge M, Brasier A . Angiotensin II induces interleukin-6 transcription in vascular smooth muscle cells through pleiotropic activation of nuclear factor-kappa B transcription factors. Circ Res. 1999; 84(6):695-703. DOI: 10.1161/01.res.84.6.695. View

Kranzhofer R, Schmidt J, Pfeiffer C, Hagl S, Libby P, Kubler W . Angiotensin induces inflammatory activation of human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 1999; 19(7):1623-9. DOI: 10.1161/01.atv.19.7.1623. View

Ruiz-Ortega M, Esteban V, Ruperez M, Sanchez-Lopez E, Rodriguez-Vita J, Carvajal G . Renal and vascular hypertension-induced inflammation: role of angiotensin II. Curr Opin Nephrol Hypertens. 2006; 15(2):159-66. DOI: 10.1097/01.mnh.0000203190.34643.d4. View

Ganter U, Arcone R, Toniatti C, Morrone G, Ciliberto G . Dual control of C-reactive protein gene expression by interleukin-1 and interleukin-6. EMBO J. 1989; 8(12):3773-9. PMC: 402063. DOI: 10.1002/j.1460-2075.1989.tb08554.x. View

Khera A, McGuire D, Murphy S, Stanek H, Das S, Vongpatanasin W . Race and gender differences in C-reactive protein levels. J Am Coll Cardiol. 2005; 46(3):464-9. DOI: 10.1016/j.jacc.2005.04.051. View

10.

Villegas R, Xiang Y, Cai H, Elasy T, Cai Q, Zhang X . Lifestyle determinants of C-reactive protein in middle-aged, urban Chinese men. Nutr Metab Cardiovasc Dis. 2010; 22(3):223-30. PMC: 3143269. DOI: 10.1016/j.numecd.2010.07.007. View

11.

Koenig W, Sund M, Frohlich M, FISCHER H, Lowel H, Doring A . C-Reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort.... Circulation. 1999; 99(2):237-42. DOI: 10.1161/01.cir.99.2.237. View

12.

Simoes E Silva A, Flynn J . The renin-angiotensin-aldosterone system in 2011: role in hypertension and chronic kidney disease. Pediatr Nephrol. 2011; 27(10):1835-45. DOI: 10.1007/s00467-011-2002-y. View

13.

Savoia C, Burger D, Nishigaki N, Montezano A, Touyz R . Angiotensin II and the vascular phenotype in hypertension. Expert Rev Mol Med. 2011; 13:e11. DOI: 10.1017/S1462399411001815. View

14.

Charbonneau-Roberts G, Saudny-Unterberger H, Kuhnlein H, Egeland G . Body mass index may overestimate the prevalence of overweight and obesity among the Inuit. Int J Circumpolar Health. 2005; 64(2):163-9. DOI: 10.3402/ijch.v64i2.17969. View

15.

Yvan-Charvet L, Massiera F, Lamande N, Ailhaud G, Teboul M, Moustaid-Moussa N . Deficiency of angiotensin type 2 receptor rescues obesity but not hypertension induced by overexpression of angiotensinogen in adipose tissue. Endocrinology. 2008; 150(3):1421-8. DOI: 10.1210/en.2008-1120. View

16.

Chateau-Degat M, Dewailly E, Louchini R, Counil E, Noel M, Ferland A . Cardiovascular burden and related risk factors among Nunavik (Quebec) Inuit: insights from baseline findings in the circumpolar Inuit health in transition cohort study. Can J Cardiol. 2010; 26(6):190-6. PMC: 2903990. DOI: 10.1016/s0828-282x(10)70398-6. View

17.

Neyestani T, Salekzamani S, Kalayi A, Alavi-Majd H, HoushiarRad A, Nikooyeh B . Predictors of serum levels of high sensitivity C-reactive protein and systolic blood pressure in overweight and obese nondiabetic women in Tehran: a cross-sectional study. Metab Syndr Relat Disord. 2010; 9(1):41-7. DOI: 10.1089/met.2010.0075. View

18.

Genest J, McPherson R, Frohlich J, Anderson T, Campbell N, Carpentier A . 2009 Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult - 2009 recommendations. Can J Cardiol. 2009; 25(10):567-79. PMC: 2782500. DOI: 10.1016/s0828-282x(09)70715-9. View

19.

Cutchins A, Roman M, Devereux R, Ebbesson S, Umans J, Zhu J . Prevalence and correlates of subclinical atherosclerosis in Alaska Eskimos: the GOCADAN study. Stroke. 2008; 39(11):3079-82. PMC: 4182957. DOI: 10.1161/STROKEAHA.108.519199. View

20.

Ishii S, Karlamangla A, Bote M, Irwin M, Jacobs Jr D, Cho H . Gender, obesity and repeated elevation of C-reactive protein: data from the CARDIA cohort. PLoS One. 2012; 7(4):e36062. PMC: 3340402. DOI: 10.1371/journal.pone.0036062. View