Feline Acute Kidney Injury: 1. Pathophysiology, Etiology and Etiology-specific Management Considerations

Overview

Journal J Feline Med Surg

Specialty Veterinary Medicine

Date 2012 Oct 23

PMID 23087003

Citations 9

Authors

Kelly Monaghan

Benjamin Nolan

Mary Labato

Affiliations

Soon will be listed here.

Abstract

Practical Relevance: Acute kidney injury (AKI) is a frequently recognized disease process in cats that requires immediate and aggressive intervention. A thorough understanding of the pathophysiologic processes underlying AKI and familiarity with the most common etiologies are essential for providing the most effective and timely therapy. Possessing this knowledge will also allow a more accurate prognosis to be given, and afford the best chance of a favorable outcome.

Clinical Challenges: Feline patients often present with vague signs of AKI, which may delay treatment and adversely affect the prognosis. Their response to injury and treatment is often different to that of other species.

Audience: This two-part review article is directed at small animal practitioners as well as specialists. Part 1 reviews mechanisms underlying AKI in the cat, as well as etiologies and treatments related to some specific causes of AKI.

Evidence Base: The veterinary literature is limited with regards to the pathophysiology of AKI unique to the cat. However, there are numerous feline studies evaluating causes of AKI.

Citing Articles

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Symmetric dimethylarginine correlates with the urea, creatinine, potassium, and clinical scores in feline urethral obstructions.

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Urine bacterial culture growth and association with urine sedimentation and clinical findings in cats with acute kidney injury.

Siu K, Diaz A, Chadwick A, Keys D, Shropshire S, Summers S J Feline Med Surg. 2022; 24(10):e295-e301.

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Extracellular vesicles derived from mesenchymal stem cells as a potential therapeutic agent in acute kidney injury (AKI) in felines: review and perspectives.

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