Long-range Interlayer Alignment of Intralayer Domains in Stacked Lipid Bilayers

Overview

Journal Nat Mater

Date 2012 Oct 23

PMID 23085566

Citations 45

Authors

Lobat Tayebi

Yicong Ma

Daryoosh Vashaee

Gang Chen

Sunil K Sinha

Atul N Parikh

Affiliations

Soon will be listed here.

Abstract

Liquid-crystalline phases of stacked lipid bilayers represent a pervasive motif in biomolecular assemblies. Here we report that, in addition to the usual smectic order, multicomponent multilayer membranes can exhibit columnar order arising from the coupling of two-dimensional intralayer phase separation and interlayer smectic ordering. This coupling propagates across hundreds of membrane lamellae, producing long-range alignment of phase-separated domains. Quantitative analysis of real-time dynamical experiments reveals that there is an interplay between intralayer domain growth and interlayer coupling, suggesting the existence of cooperative multilayer epitaxy. We postulate that such long-range epitaxy is solvent-assisted, and that it originates from the surface tension associated with differences in the network of hydrogen-bonded water molecules at the hydrated interfaces between the domains and the surrounding phase. Our findings might inspire the development of self-assembly-based strategies for the long-range alignment of functional lipid domains.

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