The Genetic Analysis of Functional Connectomics in Drosophila

Overview

Journal Adv Genet

Specialty Genetics

Date 2012 Oct 23

PMID 23084874

Citations 22

Authors

Ian A Meinertzhagen

Chi-Hon Lee

Affiliations

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Abstract

Fly and vertebrate nervous systems share many organizational features, such as layers, columns and glomeruli, and utilize similar synaptic components, such as ion channels and receptors. Both also exhibit similar network features. Recent technological advances, especially in electron microscopy, now allow us to determine synaptic circuits and identify pathways cell-by-cell, as part of the fly's connectome. Genetic tools provide the means to identify synaptic components, as well as to record and manipulate neuronal activity, adding function to the connectome. This review discusses technical advances in these emerging areas of functional connectomics, offering prognoses in each and identifying the challenges in bridging structural connectomics to molecular biology and synaptic physiology, thereby determining fundamental mechanisms of neural computation that underlie behavior.

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