Pathophysiology of Celiac Disease

Overview

Journal Gastrointest Endosc Clin N Am

Specialties Gastroenterology
Pharmacology
Radiology

Date 2012 Oct 23

PMID 23083984

Citations 46

Authors

Sonia S Kupfer

Bana Jabri

Affiliations

Soon will be listed here.

Abstract

Celiac disease results from the interplay of genetic, environmental, and immunologic factors. An understanding of the pathophysiology of celiac disease, in which the trigger (wheat, rye, and barley) is known, will undoubtedly reveal basic mechanisms that underlie other autoimmune diseases (eg, type 1 diabetes) that share many common pathogenic perturbations. This review describes seminal findings in each of the 3 domains of the pathogenesis of celiac disease, namely genetics, environmental triggers, and immune dysregulation, with a focus on newer areas of investigation such as non-HLA genetic variants, the intestinal microbiome, and the role of the innate immune system.

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