Potential of MicroRNAs for Cancer Diagnostics, Prognostication and Therapy

Overview

Journal Curr Opin Oncol

Specialty Oncology

Date 2012 Oct 20

PMID 23079782

Citations 31

Authors

Ramiro Garzon

Guido Marcucci

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: MicroRNAs (miRNAs) are small regulatory RNAs that are frequently deregulated in cancer and have shown great potential as biomarkers for cancer diagnosis and prognostication. Recent studies also support great promise in targeting miRNAs in cancer.

Recent Findings: In this review, we will discuss the most important aspects about the use of miRNAs for the diagnosis, prognosis and therapy in cancer, including current pitfalls and future directions.

Summary: The definitive establishment of miRNAs as biomarkers and as therapeutic targets in cancer will likely have a profound impact on clinical practice and research.

Citing Articles

Identification of microRNAs Implicated in Modulating Senecionine-Induced Liver Toxicity in HepaRG Cells.

Enge A, Sprenger H, Braeuning A, Hessel-Pras S Foods. 2022; 11(4).

PMID: 35206009 PMC: 8871147. DOI: 10.3390/foods11040532.

MicroRNA-936 Targets JAG1 and Inhibits the Proliferation of Hepatocellular Carcinoma Cells.

Tian J, Zhao Y, Li L, Cui Y, Wu Y Technol Cancer Res Treat. 2021; 20:1533033820985785.

PMID: 33550933 PMC: 7876578. DOI: 10.1177/1533033820985785.

microRNA-1298 inhibits the malignant behaviors of breast cancer cells via targeting ADAM9.

Chen W, Lu Q, Li S, Zhang X, Xue X Biosci Rep. 2020; 40(12).

PMID: 33146718 PMC: 7729294. DOI: 10.1042/BSR20201215.

Long Non-Coding RNA Sponges microRNA-532 and Promotes Oncogenicity of Clear Cell Renal Cell Carcinoma by Increasing ETS1 Expression.

Luo Y, Liu F, Yan C, Qu W, Zhu L, Guo Z Cancer Manag Res. 2020; 12:2195-2207.

PMID: 32273759 PMC: 7102911. DOI: 10.2147/CMAR.S242472.

MiR-323-3p Targeting Transmembrane Protein with EGF-Like and 2 Follistatin Domain (TMEFF2) Inhibits Human Lung Cancer A549 Cell Apoptosis by Regulation of AKT and ERK Signaling Pathways.

Fan J, Zheng Z, Zeng Y, Chen X Med Sci Monit. 2020; 26:e919454.

PMID: 32009129 PMC: 7011573. DOI: 10.12659/MSM.919454.