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Structural and Compositional Changes Associated with Chlorine Inactivation of Polioviruses

Overview
Journal Appl Environ Microbiol
Specialties Environmental Health
Microbiology
Date 1979 Dec 1
PMID 230785
Citations 24
Authors
R T OBrien
J Newman
Affiliations
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Abstract

Chlorine inactivation of polioviruses resulted in the loss of viral ribonucleic acid, converting the viruses from 156S particles to 80S particles. However, it was found that virus inactivation occurred before the ribonucleic acid was released from the virions. Extraction of ribonucleic acid from partially inactivated virus suspensions indicated that chlorine inactivation was due to degradation of the ribonucleic acid before release and that ribonucleic acid loss was a secondary event. The empty 80S capsids had the same isoelectric point and ability to attach to host cells as infective virions. Thus, no major capsid conformational changes occurred during chlorine inactivation.

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References
1.
Breindl M . The structure of heated poliovirus particles. J Gen Virol. 1971; 11(3):147-56. DOI: 10.1099/0022-1317-11-3-147. View
2.
Ward R . Mechanism of poliovirus inactivation by ammonia. J Virol. 1978; 26(2):299-305. PMC: 354068. DOI: 10.1128/JVI.26.2.299-305.1978. View
3.
OBrien R, Newman J . Inactivation of polioviruses and coxsackieviruses in surface water. Appl Environ Microbiol. 1977; 33(2):334-40. PMC: 170687. DOI: 10.1128/aem.33.2.334-340.1977. View
4.
CORDS C, JAMES C, McLaren L . Alteration of capsid proteins of coxsackievirus A13 by low ionic concentrations. J Virol. 1975; 15(2):244-52. PMC: 354446. DOI: 10.1128/JVI.15.2.244-252.1975. View
5.
Ward R, Ashley C . Inactivation of poliovirus in digested sludge. Appl Environ Microbiol. 1976; 31(6):921-30. PMC: 169857. DOI: 10.1128/aem.31.6.921-930.1976. View