Chronic Rejection: a Significant Role for Th17-mediated Autoimmune Responses to Self-antigens

Overview

Journal Expert Rev Clin Immunol

Specialty Allergy & Immunology

Date 2012 Oct 20

PMID 23078063

Citations 2

Authors

Vijay Subramanian

Thalachallour Mohanakumar

Affiliations

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Abstract

Despite progress in the field of organ transplantation for improvement in graft survival and function, long-term graft function is still limited by the development of chronic allograft rejection. Various immune-mediated and nonimmune-mediated processes have been postulated in the pathogenesis of chronic rejection. In this review, the authors discuss the important role of alloimmune responses to donor-specific antigens and autoimmune responses to tissue restricted self-antigens in the immunopathogenesis of chronic rejection following solid organ transplantation. In particular, the authors discuss the role of induction of Th17-type autoimmune responses and the crosstalk between autoimmune and alloimmune responses. These self-perpetuate each other leading to activation of profibrotic and proinflammatory cascades that ultimately result in the development of chronic rejection.

Citing Articles

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Transplant genetics and genomics.

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