The AdmiR-able Advances in Cardiovascular Biology Through the Zebrafish Model System

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2012 Oct 17

PMID 23069988

Citations 2

Authors

Dafne Gays

Massimo Mattia Santoro

Affiliations

Soon will be listed here.

Abstract

MicroRNAs are small non-coding RNAs endogenously expressed by all tissues during development and adulthood. They regulate gene expression by controlling the stability of targeted messenger RNA. In cardiovascular tissues microRNAs play a role by modulating essential genes involved in heart and blood vessel development and homeostasis. The zebrafish (Danio rerio) system is a recognized vertebrate model system useful to study cardiovascular biology; recently, it has been used to investigate microRNA functions during natural and pathological states. In this review, we will illustrate the advantages of the zebrafish model in the study of microRNAs in heart and vascular cells, providing an update on recent discoveries using the zebrafish to identify new microRNAs and their targeted genes in cardiovascular tissues. Lastly, we will provide evidence that the zebrafish is an optimal model system to undercover new microRNA functions in vertebrates and to improve microRNA-based therapeutic approaches.

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