Molecular Epidemiology of Rotavirus Strains Circulating Among Children with Gastroenteritis in Iran

Overview

Journal Iran J Pediatr

Publisher Brieflands

Specialty Pediatrics

Date 2012 Oct 12

PMID 23056861

Citations 19

Authors

Mohammad Kargar

Maryam Zare

Akram Najafi

Affiliations

Soon will be listed here.

Abstract

Objective: This study was conducted to evaluate the prevalence of rotavirus disease and to investigate the genotypes of rotavirus strains causing acute gastroenteritis among children aged <5 years old in Marvdasht, Iran.

Methods: One hundred and forty-one children, aged 1 month to 5 years, afflicted with severe diarrhea were enrolled during January 2007 to December 2008. Their stool samples were studied with enzyme immunoassays (EIA) for group A rotaviruses. Rotavirus-positive specimens were genotyped by the Nested RT-PCR using different types of specific primers.

Findings: Out of total collected samples rotavirus infection was detected in 40 (28.37%). Of the rotavirus episodes, 72.91% occurred during the first 2 years of life (P=0.038). The highest prevalence of infection was identified in summer (52.50%) and the lowest in winter (7.50%). The most common clinical features included diarrhea (96.25%), vomiting (82.50%) and fever (45.0%). Mixed genotypes were the predominant G type (60.0%), followed by non-typeable (12.50%), G2 (12.50%), G4 (10.0%) and G1 (5.0%) genotypes. G3/G8 mixed infection is the first of these rotavirus genotypes to be reported in Iran.

Conclusion: Regarding high frequency of rotavirus infection, continuous surveillance is needed to inform diarrhea prevention programs as well as to provide information about the occurrence of new rotavirus strains. This will assist policy makers in decision making on rotavirus vaccine introduction.

Citing Articles

The Frequency of Rotavirus Gastroenteritis in Children from West of Iran and Genotyping of Rotavirus Isolates: A Suggestion for Further Changes in Childhood Immunization Program.

Sedighi P, Karami M, Razzaghi M, Emamjamaat M, Karimi A, Ghanaiee R J Res Health Sci. 2024; 24(3):e00621.

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Circulating rotavirus strains in children with acute gastroenteritis in Iran, 1986 to 2023 and their genetic/antigenic divergence compared to approved vaccines strains (Rotarix, RotaTeq, ROTAVAC, ROTASIIL) before mass vaccination: Clues for....

Jalilvand S, Latifi T, Kachooei A, Mirhoseinian M, Hoseini-Fakhr S, Behnezhad F Virus Res. 2024; 346:199411.

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Rotavirus epidemiology adjusted pattern in a tropical setting: mathematical correction for false positive problem relating to primary immunochromatography test surveillance.

Mungmunpuntipantip R, Wiwanitkit V Int J Biochem Mol Biol. 2023; 13(6):54-59.

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Prevalence and seasonal pattern of enteric viruses among hospitalized children with acute gastroenteritis in Samawah, Iraq.

Thwiny H, Alsalih N, Saeed Z, Al-Yasari A, Al-Saadawe M, Alsaadawi M J Med Life. 2022; 15(1):52-57.

PMID: 35186136 PMC: 8852632. DOI: 10.25122/jml-2021-0158.

Detection and characterization of rotavirus G and P types from children with acute gastroenteritis in Qom, central Iran.

Shams S, Mousavi Nasab S, Heydari H, Tafaroji J, Ahmadi N, Shams Afzali E Gastroenterol Hepatol Bed Bench. 2021; 13(Suppl1):S128-S133.

PMID: 33585014 PMC: 7881410.

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