Retinopathy of Prematurity in Infants with Late Retinal Examination

Overview

Journal J Ophthalmic Vis Res

Specialty Ophthalmology

Date 2012 Oct 12

PMID 23056670

Citations 7

Authors

S Zeinab Mousavi

Reza Karkhaneh

Mohammad Riazi-Esfahani

Mohammad-Reza Mansouri

Ramak Roohipoor

Leila Ghalichi

Malihe Kadivar

Mehdi Nili-Ahmadabadi

Fatemeh Naieri

Affiliations

Soon will be listed here.

Abstract

Purpose: To report the incidence, severity and risk factors of retinopathy of prematurity (ROP) in premature infants with late ROP examination in Farabi Eye Hospital.

Methods: In a retrospective study from January 2001 to July 2007, hospital records of premature infants who were examined later than 9 weeks after birth were reviewed to determine the incidence, severity and possible risk factors of ROP including gender, singleton or multiple gestations, gestational age (GA), birth weight (BW), oxygen therapy,blood transfusion, phototherapy, respiratory distress syndrome (RDS), mechanical ventilation,intraventricular hemorrhage and sepsis as well as age at initial examination.

Results: Out of a total of 797 infants referred for ROP screening during the study period,216 (27.1%) had late examinations at a mean age of 141.7± 150.4 (range 64-1,460) days. Of these, 87 (40.3%) had different stages of ROP, 65 (30.1%) had stage 4 or 5 disease including 34 (16.2%) infants with stage 5 ROP in both eyes which was untreatable. Lower GA (P<0.001), RDS (P=0.041) and blood transfusion (P=0.009) were associated with the development of ROP.

Conclusion: The overall prevalence of ROP and the incidence of severe ROP in particular,were unacceptably high in premature infants with late screening. These findings necessitate interventions to optimize timely referral for screening of premature infants.

Citing Articles

Impact of COVID-19 Pandemic on Retinopathy of Prematurity Services in the Indian Public Healthcare System.

Chakraborty S, Sheth J Clin Ophthalmol. 2023; 17:2871-2877.

PMID: 37808002 PMC: 10558049. DOI: 10.2147/OPTH.S426219.

Twelve-year profile of screening results of retinopathy of prematurity at a tertiary care institute in Northwest China.

Yan H, Li M, Wang L, Wu L, Fan J, Zhou Y Int J Ophthalmol. 2022; 15(2):312-319.

PMID: 35186693 PMC: 8818447. DOI: 10.18240/ijo.2022.02.18.

Demographic profile and ocular characteristics of stage 5 retinopathy of prematurity at a referral center in Northwest China: implications for implementation.

Dou G, Li M, Zhang Z, Lu Y, Zhu Y, Wang H BMC Ophthalmol. 2018; 18(1):307.

PMID: 30497419 PMC: 6267009. DOI: 10.1186/s12886-018-0975-z.

Prevalence and risk factors of retinopathy of prematurity in Iran: a systematic review and meta-analysis.

Azami M, Jaafari Z, Rahmati S, Dastjani Farahani A, Badfar G BMC Ophthalmol. 2018; 18(1):83.

PMID: 29606108 PMC: 5879798. DOI: 10.1186/s12886-018-0732-3.

Prevalence of retinopathy of prematurity in Iran: a systematic review and Meta-analysis.

Maroufizadeh S, Almasi-Hashiani A, Omani Samani R, Sepidarkish M Int J Ophthalmol. 2017; 10(8):1273-1279.

PMID: 28861355 PMC: 5554848. DOI: 10.18240/ijo.2017.08.15.

References

Gilbert C, Foster A . Childhood blindness in the context of VISION 2020--the right to sight. Bull World Health Organ. 2001; 79(3):227-32. PMC: 2566382. View

Palmer E . Optimal timing of examination for acute retrolental fibroplasia. Ophthalmology. 1981; 88(7):662-8. DOI: 10.1016/s0161-6420(81)34980-x. View

Clemett R, Darlow B . Results of screening low-birth-weight infants for retinopathy of prematurity. Curr Opin Ophthalmol. 1999; 10(3):155-63. DOI: 10.1097/00055735-199906000-00001. View

Binkhathlan A, Almahmoud L, Saleh M, Srungeri S . Retinopathy of prematurity in Saudi Arabia: incidence, risk factors, and the applicability of current screening criteria. Br J Ophthalmol. 2008; 92(2):167-9. DOI: 10.1136/bjo.2007.126508. View

. Multicenter trial of cryotherapy for retinopathy of prematurity. Preliminary results. Cryotherapy for Retinopathy of Prematurity Cooperative Group. Arch Ophthalmol. 1988; 106(4):471-9. DOI: 10.1001/archopht.1988.01060130517027. View

Hagadorn J, Richardson D, Schmid C, Cole C . Cumulative illness severity and progression from moderate to severe retinopathy of prematurity. J Perinatol. 2007; 27(8):502-9. DOI: 10.1038/sj.jp.7211780. View

McColm J, Fleck B . Retinopathy of prematurity: causation. Semin Neonatol. 2002; 6(6):453-60. DOI: 10.1053/siny.2001.0079. View

. Screening examination of premature infants for retinopathy of prematurity. Pediatrics. 2001; 108(3):809-11. DOI: 10.1542/peds.108.3.809. View

OKeefe M, Kirwan C . Screening for retinopathy of prematurity. Early Hum Dev. 2008; 84(2):89-94. DOI: 10.1016/j.earlhumdev.2007.11.006. View

10.

Attar M, Gates M, Iatrow A, Lang S, Bratton S . Barriers to screening infants for retinopathy of prematurity after discharge or transfer from a neonatal intensive care unit. J Perinatol. 2004; 25(1):36-40. DOI: 10.1038/sj.jp.7211203. View

11.

Azad R, Chandra P . Retinopathy of prematurity. J Indian Med Assoc. 2005; 103(7):370-2. View

12.

Gilbert C, Fielder A, Gordillo L, Quinn G, Semiglia R, Visintin P . Characteristics of infants with severe retinopathy of prematurity in countries with low, moderate, and high levels of development: implications for screening programs. Pediatrics. 2005; 115(5):e518-25. DOI: 10.1542/peds.2004-1180. View

13.

Saugstad O . Oxygen and retinopathy of prematurity. J Perinatol. 2006; 26 Suppl 1:S46-50. DOI: 10.1038/sj.jp.7211475. View

14.

Gilbert C . Retinopathy of prematurity: a global perspective of the epidemics, population of babies at risk and implications for control. Early Hum Dev. 2008; 84(2):77-82. DOI: 10.1016/j.earlhumdev.2007.11.009. View

15.

. Revised indications for the treatment of retinopathy of prematurity: results of the early treatment for retinopathy of prematurity randomized trial. Arch Ophthalmol. 2003; 121(12):1684-94. DOI: 10.1001/archopht.121.12.1684. View

16.

Shah V, Yeo C, Ling Y, Ho L . Incidence, risk factors of retinopathy of prematurity among very low birth weight infants in Singapore. Ann Acad Med Singap. 2005; 34(2):169-78. View

17.

. Screening examination of premature infants for retinopathy of prematurity. Pediatrics. 2006; 117(2):572-6. DOI: 10.1542/peds.2005-2749. View

18.

Seiberth V, Linderkamp O . Risk factors in retinopathy of prematurity. a multivariate statistical analysis. Ophthalmologica. 2000; 214(2):131-5. DOI: 10.1159/000027482. View

19.

Fortes Filho J, Eckert G, Procianoy L, Barros C, Procianoy R . Incidence and risk factors for retinopathy of prematurity in very low and in extremely low birth weight infants in a unit-based approach in southern Brazil. Eye (Lond). 2007; 23(1):25-30. DOI: 10.1038/sj.eye.6702924. View

20.

Akkoyun I, Oto S, Yilmaz G, Gurakan B, Tarcan A, Anuk D . Risk factors in the development of mild and severe retinopathy of prematurity. J AAPOS. 2006; 10(5):449-53. DOI: 10.1016/j.jaapos.2006.05.007. View