Novel Non-invasive Method of Measurement of Endothelial Function: Enclosed-zone Flow-mediated Dilatation (ezFMD)

Overview

Journal Med Biol Eng Comput

Publisher Springer

Specialties Biomedical Engineering
Medical Informatics

Date 2012 Oct 12

PMID 23054376

Citations 5

Authors

Teiji Ukawa

Tsuneo Takayanagi

Haruka Morimoto

Yukihito Higashi

Naomi Idei

Masao Yoshizumi

Toshio Tsuji

Affiliations

Soon will be listed here.

Abstract

Measurement of flow-mediated dilatation (FMD) is the conventional non-invasive method for assessment of endothelial function; however, it requires an expensive ultrasound system and high levels of technical skill. Therefore, we developed a novel method for measurement of endothelial function, namely, measurement of ezFMD. ezFMD estimates the degree of vasodilatation from the oscillation signals transmitted to a sphygmomanometer cuff attached to the upper arm. The objective of this study was to validate the principle underlying the measurement of ezFMD, and to evaluate the repeatability of the ezFMD measurements. We observed the blood vessel behavior and oscillometric pattern in ten subjects. When the cuff was inflated to the level of the mean blood pressure, the oscillation amplitude increased with increasing degree of vasodilatation. In experiment to evaluate the repeatability of the ezFMD measurement, the average difference between the paired measurements was 3.7 %, the standard deviation was 11.5 %, and the average coefficient of variation value for the 11 paired measurements was 23.7 %. These results suggest the validity of the principle underlying the measurement of the ezFMD for the assessment of endothelial function. And, this study suggests that the repeatability of the ezFMD measurements is superior to that of the conventional measurement of FMD.

Citing Articles

Peripheral arterial elasticity changes derived by volume-oscillometry in reaction to hyperemia as a possible assessment of flow-mediated vasodilatation.

Yamakoshi T, Rolfe P, Yamakoshi K Sci Rep. 2022; 12(1):19479.

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Estimation of Arterial Viscosity Based on an Oscillometric Method and Its Application in Evaluating the Vascular Endothelial Function.

Tanaka H, Mito A, Hirano H, Soh Z, Nakamura R, Saeki N Sci Rep. 2019; 9(1):2609.

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Relation between blood pressure and pulse wave velocity for human arteries.

Ma Y, Choi J, Hourlier-Fargette A, Xue Y, Chung H, Lee J Proc Natl Acad Sci U S A. 2018; 115(44):11144-11149.

PMID: 30322935 PMC: 6217416. DOI: 10.1073/pnas.1814392115.

Assessment of Lower-limb Vascular Endothelial Function Based on Enclosed Zone Flow-mediated Dilation.

Hirano H, Takama R, Matsumoto R, Tanaka H, Hirano H, Soh Z Sci Rep. 2018; 8(1):9263.

PMID: 29915185 PMC: 6006353. DOI: 10.1038/s41598-018-27392-3.

Endothelial Function Assessed by Automatic Measurement of Enclosed Zone Flow-Mediated Vasodilation Using an Oscillometric Method Is an Independent Predictor of Cardiovascular Events.

Morimoto H, Kajikawa M, Oda N, Idei N, Hirano H, Hida E J Am Heart Assoc. 2016; 5(12).

PMID: 28003249 PMC: 5210444. DOI: 10.1161/JAHA.116.004385.

References

Bland J, Altman D . Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986; 1(8476):307-10. View

Corretti M, Anderson T, Benjamin E, Celermajer D, Charbonneau F, Creager M . Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol. 2002; 39(2):257-65. DOI: 10.1016/s0735-1097(01)01746-6. View

Bank A, Wilson R, Kubo S, Holte J, Dresing T, Wang H . Direct effects of smooth muscle relaxation and contraction on in vivo human brachial artery elastic properties. Circ Res. 1995; 77(5):1008-16. DOI: 10.1161/01.res.77.5.1008. View

Meyer B, Mortl D, Strecker K, Hulsmann M, Kulemann V, Neunteufl T . Flow-mediated vasodilation predicts outcome in patients with chronic heart failure: comparison with B-type natriuretic peptide. J Am Coll Cardiol. 2005; 46(6):1011-8. DOI: 10.1016/j.jacc.2005.04.060. View

Celermajer D, Sorensen K, Gooch V, Spiegelhalter D, Miller O, Sullivan I . Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet. 1992; 340(8828):1111-5. DOI: 10.1016/0140-6736(92)93147-f. View

Ramsey 3rd M . Noninvasive automatic determination of mean arterial pressure. Med Biol Eng Comput. 1979; 17(1):11-8. DOI: 10.1007/BF02440948. View

Peretz A, Leotta D, Sullivan J, Trenga C, Sands F, Aulet M . Flow mediated dilation of the brachial artery: an investigation of methods requiring further standardization. BMC Cardiovasc Disord. 2007; 7:11. PMC: 1847451. DOI: 10.1186/1471-2261-7-11. View

Yeboah J, Folsom A, Burke G, Johnson C, Polak J, Post W . Predictive value of brachial flow-mediated dilation for incident cardiovascular events in a population-based study: the multi-ethnic study of atherosclerosis. Circulation. 2009; 120(6):502-9. PMC: 2740975. DOI: 10.1161/CIRCULATIONAHA.109.864801. View

Harris R, Padilla J, Rink L, Wallace J . Variability of flow-mediated dilation measurements with repetitive reactive hyperemia. Vasc Med. 2006; 11(1):1-6. DOI: 10.1191/1358863x06vm641oa. View

10.

Michard F . Changes in arterial pressure during mechanical ventilation. Anesthesiology. 2005; 103(2):419-28. DOI: 10.1097/00000542-200508000-00026. View

11.

Malik J, Wichterle D, Haas T, Melenovsky V, Simek J, Stulc T . Repeatability of noninvasive surrogates of endothelial function. Am J Cardiol. 2004; 94(5):693-6. DOI: 10.1016/j.amjcard.2004.05.049. View

12.

Mauck G, Smith C, Geddes L, Bourland J . The meaning of the point of maximum oscillations in cuff pressure in the indirect measurement of blood pressure--part ii. J Biomech Eng. 1980; 102(1):28-33. DOI: 10.1115/1.3138195. View

13.

Ross R . Atherosclerosis--an inflammatory disease. N Engl J Med. 1999; 340(2):115-26. DOI: 10.1056/NEJM199901143400207. View

14.

Roman M, Naqvi T, Gardin J, Gerhard-Herman M, Jaff M, Mohler E . Clinical application of noninvasive vascular ultrasound in cardiovascular risk stratification: a report from the American Society of Echocardiography and the Society of Vascular Medicine and Biology. J Am Soc Echocardiogr. 2006; 19(8):943-54. DOI: 10.1016/j.echo.2006.04.020. View

15.

Soga J, Nishioka K, Nakamura S, Umemura T, Jitsuiki D, Hidaka T . Measurement of flow-mediated vasodilation of the brachial artery: a comparison of measurements in the seated and supine positions. Circ J. 2007; 71(5):736-40. DOI: 10.1253/circj.71.736. View

16.

Chinn S . The assessment of methods of measurement. Stat Med. 1990; 9(4):351-62. DOI: 10.1002/sim.4780090402. View