Autism Traits in Individuals with Agenesis of the Corpus Callosum

Overview

Journal J Autism Dev Disord

Publisher Springer

Date 2012 Oct 12

PMID 23054201

Citations 37

Authors

Yolanda C Lau

Leighton B N Hinkley

Polina Bukshpun

Zoe A Strominger

Mari L J Wakahiro

Simon Baron-Cohen

Carrie Allison

Bonnie Auyeung

Rita J Jeremy

Srikantan S Nagarajan

Elliott H Sherr

Elysa J Marco

Affiliations

Soon will be listed here.

Abstract

Autism spectrum disorders (ASD) have numerous etiologies, including structural brain malformations such as agenesis of the corpus callosum (AgCC). We sought to directly measure the occurrence of autism traits in a cohort of individuals with AgCC and to investigate the neural underpinnings of this association. We screened a large AgCC cohort (n = 106) with the Autism Spectrum Quotient (AQ) and found that 45 % of children, 35 % of adolescents, and 18 % of adults exceeded the predetermined autism-screening cut-off. Interestingly, performance on the AQ's imagination domain was inversely correlated with magnetoencephalography measures of resting-state functional connectivity in the right superior temporal gyrus. Individuals with AgCC should be screened for ASD and disorders of the corpus callosum should be considered in autism diagnostic evaluations as well.

Citing Articles

Social and Communication Development in Infants with Isolated Agenesis of the Corpus Callosum.

Paul L, Turner J, Sung S, Elison J J Pediatr Clin Pract. 2025; 14:200118.

PMID: 39950051 PMC: 11824658. DOI: 10.1016/j.jpedcp.2024.200118.

Individuals with high autistic traits exhibit altered interhemispheric brain functional connectivity patterns.

Wang J, Zhang L, Chen S, Xue H, Du M, Xu Y Cogn Neurodyn. 2025; 19(1):9.

PMID: 39801910 PMC: 11717774. DOI: 10.1007/s11571-024-10213-x.

The Genetic Architecture of the Human Corpus Callosum and its Subregions.

Bhatt R, Gadewar S, Shetty A, Ba Gari I, Haddad E, Javid S bioRxiv. 2024; .

PMID: 39091796 PMC: 11291056. DOI: 10.1101/2024.07.22.603147.

Molecular mechanisms of corpus callosum development: a four-step journey.

Gavrish M, Kustova A, Celis Suescun J, Bessa P, Mitina N, Tarabykin V Front Neuroanat. 2024; 17:1276325.

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CUT homeobox genes: transcriptional regulation of neuronal specification and beyond.

Leyva-Diaz E Front Cell Neurosci. 2023; 17:1233830.

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