The Effects of Topical Treatment with Curcumin on Burn Wound Healing in Rats

Overview

Journal J Mol Histol

Specialty Biochemistry

Date 2012 Oct 12

PMID 23054142

Citations 55

Authors

Mustafa Kulac

Cevat Aktas

Feti Tulubas

Ramazan Uygur

Mehmet Kanter

Mustafa Erboga

Mehmet Ceber

Birol Topcu

Oguz Aslan Ozen

Affiliations

Soon will be listed here.

Abstract

The present study was designed to determine the role of topical treatment with curcumin (Cur) on burn wound healing in rats. The Wistar-albino rats were randomly allotted into one of three experimental groups: 4th, 8th and 12th day (post burn) and all groups include subgroups which Burn and Burn + Cur. Each group contains 12 animals. Burn wounds were made on the back of rat and Cur was administered topically. At the end of the study, all animals were sacrificed and the wound tissues removed for analyse to biochemical and histopathological changes. There was a significant increase in the hydroxyproline levels in the skin of the Cur groups. Cur treated wounds were found to heal much faster as indicated by improved rates of inflammatory cells, collagen deposition, angiogenesis, granulation tissue formation and epithelialization which were also confirmed by histopathological and biochemical examinations. Our data also indicate that there is a rise in the expression of proliferating cell nuclear antigen in skin tissues of Cur-treated rats in the Burn group. The results clearly substantiate the beneficial effects of the topical application of Cur in the acceleration of wound healing.

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References

Chung A, Kao W . Fibroblasts regulate monocyte response to ECM-derived matrix: the effects on monocyte adhesion and the production of inflammatory, matrix remodeling, and growth factor proteins. J Biomed Mater Res A. 2009; 89(4):841-53. PMC: 3795518. DOI: 10.1002/jbm.a.32431. View

Singer A, McClain S, Romanov A, Rooney J, Zimmerman T . Curcumin reduces burn progression in rats. Acad Emerg Med. 2007; 14(12):1125-9. DOI: 10.1197/j.aem.2007.07.012. View

Yu L, Yi J, Ye G, Zheng Y, Song Z, Yang Y . Effects of curcumin on levels of nitric oxide synthase and AQP-4 in a rat model of hypoxia-ischemic brain damage. Brain Res. 2012; 1475:88-95. DOI: 10.1016/j.brainres.2012.07.055. View

Phan T, See P, Lee S, Chan S . Protective effects of curcumin against oxidative damage on skin cells in vitro: its implication for wound healing. J Trauma. 2001; 51(5):927-31. DOI: 10.1097/00005373-200111000-00017. View

Panchatcharam M, Miriyala S, Gayathri V, Suguna L . Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species. Mol Cell Biochem. 2006; 290(1-2):87-96. DOI: 10.1007/s11010-006-9170-2. View

Sidhu G, Mani H, Gaddipati J, Singh A, Seth P, Banaudha K . Curcumin enhances wound healing in streptozotocin induced diabetic rats and genetically diabetic mice. Wound Repair Regen. 1999; 7(5):362-74. DOI: 10.1046/j.1524-475x.1999.00362.x. View

Schlager A, Oehler K, Huebner K, Schmuth M, Spoetl L . Healing of burns after treatment with 670-nanometer low-power laser light. Plast Reconstr Surg. 2000; 105(5):1635-9. DOI: 10.1097/00006534-200004050-00006. View

Foschi D, Trabucchi E, Musazzi M, Castoldi L, Di Mattia D, Radaelli E . The effects of oxygen free radicals on wound healing. Int J Tissue React. 1988; 10(6):373-9. View

Hsu S, RAINE L, FANGER H . Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem. 1981; 29(4):577-80. DOI: 10.1177/29.4.6166661. View

10.

Li X, Chen S, Zhang B, Li M, Diao K, Zhang Z . In situ injectable nano-composite hydrogel composed of curcumin, N,O-carboxymethyl chitosan and oxidized alginate for wound healing application. Int J Pharm. 2012; 437(1-2):110-9. DOI: 10.1016/j.ijpharm.2012.08.001. View

11.

Youn Y, Lalonde C, Demling R . The role of mediators in the response to thermal injury. World J Surg. 1992; 16(1):30-6. DOI: 10.1007/BF02067111. View

12.

Jagetia G, Rajanikant G . Effect of curcumin on radiation-impaired healing of excisional wounds in mice. J Wound Care. 2004; 13(3):107-9. DOI: 10.12968/jowc.2004.13.3.26589. View

13.

Sidhu G, Singh A, Thaloor D, Banaudha K, Patnaik G, Srimal R . Enhancement of wound healing by curcumin in animals. Wound Repair Regen. 1998; 6(2):167-77. DOI: 10.1046/j.1524-475x.1998.60211.x. View

14.

Eigner D, Scholz D . Ferula asa-foetida and Curcuma longa in traditional medical treatment and diet in Nepal. J Ethnopharmacol. 2000; 67(1):1-6. DOI: 10.1016/s0378-8741(98)00234-7. View

15.

Gopinath D, Ahmed M, Gomathi K, Chitra K, Sehgal P, Jayakumar R . Dermal wound healing processes with curcumin incorporated collagen films. Biomaterials. 2004; 25(10):1911-7. DOI: 10.1016/s0142-9612(03)00625-2. View

16.

Haycock J, Ralston D, Morris B, Freedlander E, MacNeil S . Oxidative damage to protein and alterations to antioxidant levels in human cutaneous thermal injury. Burns. 1998; 23(7-8):533-40. DOI: 10.1016/s0305-4179(97)00072-7. View

17.

Wen H, Wu G, Chen W, Yang H, Fu J . [Topical application of leptin promotes burn wound healing in rats]. Nan Fang Yi Ke Da Xue Xue Bao. 2012; 32(5):703-6. View

18.

Yucel A, Kanter M, Pergel A, Erboga M, Guzel A . The role of curcumin on intestinal oxidative stress, cell proliferation and apoptosis after ischemia/reperfusion injury in rats. J Mol Histol. 2011; 42(6):579-87. DOI: 10.1007/s10735-011-9364-0. View

19.

Aktas C, Kanter M, Erboga M, Ozturk S . Anti-apoptotic effects of curcumin on cadmium-induced apoptosis in rat testes. Toxicol Ind Health. 2011; 28(2):122-30. DOI: 10.1177/0748233711407242. View

20.

Worsfold M, Davie M, Haddaway M . Age-related changes in body composition, hydroxyproline, and creatinine excretion in normal women. Calcif Tissue Int. 1998; 64(1):40-4. DOI: 10.1007/s002239900576. View