Genetic Variability and Haplotype Profile of MDR1 in Saudi Arabian Males

Overview

Journal Mol Biol Rep

Specialty Molecular Biology

Date 2012 Oct 12

PMID 23053935

Citations 4

Authors

Abdullah M Al-Mohizea

Khalid M Alkharfy

Khawla M Bagulb

Amal M Alghamdi

Fahad I Al-Jenoobi

Saleh Al-Muhsen

Rabih Halwani

Mohammad Khalid Parvez

M Khalid Parvez

Mohammed S Al-Dosari

Affiliations

Soon will be listed here.

Abstract

Polymorphisms in multidrug resistance (MDR1) gene play an important role in influencing the pharmacological action and toxicity profile of a large number of therapeutic agents, and in human susceptibility to various diseases. Because of genotypic variability, several studies were directed toward determination of the frequencies of MDR1 polymorphisms and/or haplotypes in different ethnic populations. In this study, we determined the frequencies of the most common three polymorphisms in the MDR1 gene (i.e., C1236T, G2677T, and C3435T) in Saudi Arabians and their haplotypes. Our results showed that the frequencies of 1236T, 2677T, and 3435T were 43.7 %, 40.2 %, and 42.2 %, respectively. In addition, the frequencies of the most common MDR1 haplotypes, C-G-C and T-T-T, were correspondent to 48.8 and 35.5 %. Furthermore, we identified moderate to strong linkage disequilibrium between the loci of these single nucleotide polymorphisms in the studied subjects. These identified frequencies in Saudi Arabians are different from that reported in the other ethnic groups.

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