Diversity of IL-17-producing T Lymphocytes

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2012 Oct 12

PMID 23052209

Citations 25

Authors

Jiyeon S Kim

Martha S Jordan

Affiliations

Soon will be listed here.

Abstract

Interleukin (IL)-17 is a pro-inflammatory cytokine that plays critical roles in host defense against extracellular bacteria and fungi and also in the pathogenesis of autoimmune diseases. While CD4+ TCRαβ+ T helper (Th) 17 cells are the best-described cellular source of IL-17, many innate-like T cells are in fact potent producers of IL-17. Given the increasing interest in therapeutic modulation of the IL-17 axis, it is crucial to better understand the cellular origins of IL-17 in various infection and diseases settings. While the diverse population of IL-17-producing T cells share many common characteristics, notable differences also exist. In this review, we discuss the heterogeneity of IL-17-producing T cell types focusing on their development, regulation, and function.

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References

Evans H, Suddason T, Jackson I, Taams L, Lord G . Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes. Proc Natl Acad Sci U S A. 2007; 104(43):17034-9. PMC: 2040448. DOI: 10.1073/pnas.0708426104. View

Chen G, Hardy K, Pagler E, Ma L, Lee S, Gerondakis S . The NF-κB transcription factor c-Rel is required for Th17 effector cell development in experimental autoimmune encephalomyelitis. J Immunol. 2011; 187(9):4483-91. DOI: 10.4049/jimmunol.1101757. View

Papp K, Leonardi C, Menter A, Ortonne J, Krueger J, Kricorian G . Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis. N Engl J Med. 2012; 366(13):1181-9. DOI: 10.1056/NEJMoa1109017. View

He Y, Deftos M, Ojala E, Bevan M . RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells. Immunity. 1999; 9(6):797-806. PMC: 2776668. DOI: 10.1016/s1074-7613(00)80645-7. View

Raffatellu M, Santos R, Verhoeven D, George M, Wilson R, Winter S . Simian immunodeficiency virus-induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut. Nat Med. 2008; 14(4):421-8. PMC: 2901863. DOI: 10.1038/nm1743. View

Martin B, Hirota K, Cua D, Stockinger B, Veldhoen M . Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals. Immunity. 2009; 31(2):321-30. DOI: 10.1016/j.immuni.2009.06.020. View

Panitch H, Hirsch R, Haley A, Johnson K . Exacerbations of multiple sclerosis in patients treated with gamma interferon. Lancet. 1987; 1(8538):893-5. DOI: 10.1016/s0140-6736(87)92863-7. View

Bettelli E, Carrier Y, Gao W, Korn T, Strom T, Oukka M . Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006; 441(7090):235-8. DOI: 10.1038/nature04753. View

Dang E, Barbi J, Yang H, Jinasena D, Yu H, Zheng Y . Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Cell. 2011; 146(5):772-84. PMC: 3387678. DOI: 10.1016/j.cell.2011.07.033. View

10.

Ye P, Garvey P, Zhang P, Nelson S, Bagby G, Summer W . Interleukin-17 and lung host defense against Klebsiella pneumoniae infection. Am J Respir Cell Mol Biol. 2001; 25(3):335-40. DOI: 10.1165/ajrcmb.25.3.4424. View

11.

Veldhoen M, Hocking R, Atkins C, Locksley R, Stockinger B . TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity. 2006; 24(2):179-89. DOI: 10.1016/j.immuni.2006.01.001. View

12.

Xie Y, Sheng W, Xiang J, Ye Z, Yang J . Interleukin-17F suppresses hepatocarcinoma cell growth via inhibition of tumor angiogenesis. Cancer Invest. 2010; 28(6):598-607. DOI: 10.3109/07357900903287030. View

13.

Lockhart E, Green A, Flynn J . IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection. J Immunol. 2006; 177(7):4662-9. DOI: 10.4049/jimmunol.177.7.4662. View

14.

Turchinovich G, Pennington D . T cell receptor signalling in γδ cell development: strength isn't everything. Trends Immunol. 2011; 32(12):567-73. DOI: 10.1016/j.it.2011.09.005. View

15.

Matusevicius D, Kivisakk P, He B, Kostulas N, Ozenci V, Fredrikson S . Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis. Mult Scler. 1999; 5(2):101-4. DOI: 10.1177/135245859900500206. View

16.

Kryczek I, Wei S, Zou L, Altuwaijri S, Szeliga W, Kolls J . Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironment. J Immunol. 2007; 178(11):6730-3. DOI: 10.4049/jimmunol.178.11.6730. View

17.

Ivanov I, de Llanos Frutos R, Manel N, Yoshinaga K, Rifkin D, Sartor R . Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe. 2008; 4(4):337-49. PMC: 2597589. DOI: 10.1016/j.chom.2008.09.009. View

18.

Geddes K, Rubino S, Magalhaes J, Streutker C, Le Bourhis L, Cho J . Identification of an innate T helper type 17 response to intestinal bacterial pathogens. Nat Med. 2011; 17(7):837-44. DOI: 10.1038/nm.2391. View

19.

Spits H, Di Santo J . The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling. Nat Immunol. 2010; 12(1):21-7. DOI: 10.1038/ni.1962. View

20.

Ciric B, El-Behi M, Cabrera R, Zhang G, Rostami A . IL-23 drives pathogenic IL-17-producing CD8+ T cells. J Immunol. 2009; 182(9):5296-305. DOI: 10.4049/jimmunol.0900036. View