Anti-inflammatory and Anti-arthritic Activities of 3,4-dihydro-2,2-dimethyl-2H-naphthol[1,2-b]pyran-5,6-dione (β-lapachone)

Overview

Journal Inflamm Res

Specialties Allergy & Immunology
Pathology

Date 2012 Oct 12

PMID 23052183

Citations 14

Authors

Marilia Maria Sitonio

Carlson H R de Carvalho Junior

Ingrid de A Campos

Jose Bruno Nunes Ferreira Silva

Maria do Carmo Alves de Lima

Alexandre J S Goes

Maria Bernadete Sousa Maia

Pedro J Rolim Neto

Teresinha G Silva

Affiliations

Soon will be listed here.

Abstract

Objective And Design: The purpose of this study was to evaluate the anti-inflammatory and anti-arthritic activities of 3,4-dihydro-2,2-dimethyl-2H-naphthol[1,2-b]pyran-5,6-dione (β-lapachone; β-lap) and to elucidate its probable mode of action.

Methods: Carrageenan-induced paw edema, cell migration evaluation and production of pro-inflammatory cytokines tumor necrosis factor (TNF)-α, interleukin (IL)-6 and nitric oxide were used for this study. Freund's complete adjuvant (FCA)-induced arthritis was used as a model of chronic inflammation. β-Lap was tested in doses of 40 and 60 mg/kg, orally.

Results: In the paw edema test, the dose of 60 mg/kg gave a higher percentage inhibition of edema (49.3 %) than control. β-Lap inhibited neutrophil migration and reduced concentrations of TNF-α, IL-6 and NO in peritoneal exudates of animals with peritonitis. In the arthritis test, β-lap inhibited edema and NO production in the serum of treated animals.

Conclusion: Significant anti-inflammatory and anti-arthritic activities were observed in animals treated with β-lap. The effects of β-lap can be attributed in part to immunomodulation with reduction of pro-inflammatory cytokines and NO.

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