On the Issue of Transmissibility of Alzheimer Disease: a Critical Review

Overview

Journal Prion

Specialty Biochemistry

Date 2012 Oct 12

PMID 23052009

Citations 3

Authors

Christian Schmidt

Andre Karch

Carsten Korth

Inga Zerr

Affiliations

Soon will be listed here.

Abstract

Results from recent experiments with rodents imply that Alzheimer disease might be inducible by seeding Aβ peptides into recipient animals. In respect to this new experimental data, public health aspects as well as epidemiological data have to be reevaluated. In this article, the available experimental and epidemiological data are reviewed.

Citing Articles

Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism.

Mukherjee A, Morales-Scheihing D, Salvadores N, Moreno-Gonzalez I, Gonzalez C, Taylor-Presse K J Exp Med. 2017; 214(9):2591-2610.

PMID: 28765400 PMC: 5584114. DOI: 10.1084/jem.20161134.

Proteome-wide characterization of signalling interactions in the hippocampal CA4/DG subfield of patients with Alzheimer's disease.

Kim J, Franck J, Kang T, Heinsen H, Ravid R, Ferrer I Sci Rep. 2015; 5:11138.

PMID: 26059363 PMC: 4462342. DOI: 10.1038/srep11138.

Prions and the potential transmissibility of protein misfolding diseases.

Kraus A, Groveman B, Caughey B Annu Rev Microbiol. 2013; 67:543-64.

PMID: 23808331 PMC: 4784231. DOI: 10.1146/annurev-micro-092412-155735.

References

Schenk D, Barbour R, Dunn W, Gordon G, Grajeda H, Guido T . Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature. 1999; 400(6740):173-7. DOI: 10.1038/22124. View

Schnabel J . Amyloid: little proteins, big clues. Nature. 2011; 475(7355):S12-4. DOI: 10.1038/475S12a. View

Deatly A, Haase A, Fewster P, Lewis E, Ball M . Human herpes virus infections and Alzheimer's disease. Neuropathol Appl Neurobiol. 1990; 16(3):213-23. DOI: 10.1111/j.1365-2990.1990.tb01158.x. View

Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E . Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host. Science. 2006; 313(5794):1781-4. DOI: 10.1126/science.1131864. View

MOZAR H, Bal D, Howard J . Perspectives on the etiology of Alzheimer's disease. JAMA. 1987; 257(11):1503-7. View

MANUELIDIS E, DE FIGUEIREDO J, Kim J, Fritch W, Manuelidis L . Transmission studies from blood of Alzheimer disease patients and healthy relatives. Proc Natl Acad Sci U S A. 1988; 85(13):4898-901. PMC: 280544. DOI: 10.1073/pnas.85.13.4898. View

Fodale V, Santamaria L, Schifilliti D, Mandal P . Anaesthetics and postoperative cognitive dysfunction: a pathological mechanism mimicking Alzheimer's disease. Anaesthesia. 2010; 65(4):388-95. DOI: 10.1111/j.1365-2044.2010.06244.x. View

Aguzzi A, Rajendran L . The transcellular spread of cytosolic amyloids, prions, and prionoids. Neuron. 2010; 64(6):783-90. DOI: 10.1016/j.neuron.2009.12.016. View

Langer F, Eisele Y, Fritschi S, Staufenbiel M, Walker L, Jucker M . Soluble Aβ seeds are potent inducers of cerebral β-amyloid deposition. J Neurosci. 2011; 31(41):14488-95. PMC: 3229270. DOI: 10.1523/JNEUROSCI.3088-11.2011. View

10.

Morales R, Duran-Aniotz C, Castilla J, Estrada L, Soto C . De novo induction of amyloid-β deposition in vivo. Mol Psychiatry. 2011; 17(12):1347-53. DOI: 10.1038/mp.2011.120. View

11.

Lollis S, Valdes P, Li Z, Ball P, Roberts D . Cause-specific mortality among neurosurgeons. J Neurosurg. 2010; 113(3):474-8. DOI: 10.3171/2010.1.JNS091740. View

12.

Gautrin D, Gauthier S . Alzheimer's disease: environmental factors and etiologic hypotheses. Can J Neurol Sci. 1989; 16(4):375-87. DOI: 10.1017/s0317167100029425. View

13.

Moller J, Cluitmans P, Rasmussen L, Houx P, Rasmussen H, Canet J . Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International Study of Post-Operative Cognitive Dysfunction. Lancet. 1998; 351(9106):857-61. DOI: 10.1016/s0140-6736(97)07382-0. View

14.

Soto C, Estrada L, Castilla J . Amyloids, prions and the inherent infectious nature of misfolded protein aggregates. Trends Biochem Sci. 2006; 31(3):150-5. DOI: 10.1016/j.tibs.2006.01.002. View

15.

Zuo C, Zuo Z . Spine Surgery under general anesthesia may not increase the risk of Alzheimer's disease. Dement Geriatr Cogn Disord. 2010; 29(3):233-9. PMC: 2865396. DOI: 10.1159/000295114. View

16.

Kim J, Holtzman D . Medicine. Prion-like behavior of amyloid-beta. Science. 2010; 330(6006):918-9. DOI: 10.1126/science.1198314. View

17.

Kane M, Lipinski W, Callahan M, Bian F, Durham R, Schwarz R . Evidence for seeding of beta -amyloid by intracerebral infusion of Alzheimer brain extracts in beta -amyloid precursor protein-transgenic mice. J Neurosci. 2000; 20(10):3606-11. PMC: 6772682. View

18.

Johnson V, Stewart W, Smith D . Widespread τ and amyloid-β pathology many years after a single traumatic brain injury in humans. Brain Pathol. 2011; 22(2):142-9. PMC: 3979351. DOI: 10.1111/j.1750-3639.2011.00513.x. View

19.

DeGiorgio L, Manuelidis L, Bernstein J . Transient appearance of amyloid precursor protein plaques in the brain of thymectomized rats after human leptomeningeal cell grafts. Neurosci Lett. 2002; 322(1):62-6. DOI: 10.1016/s0304-3940(02)00065-4. View

20.

Eisele Y, Obermuller U, Heilbronner G, Baumann F, Kaeser S, Wolburg H . Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis. Science. 2010; 330(6006):980-2. PMC: 3233904. DOI: 10.1126/science.1194516. View