Movement Disorders and Neuromodulation

Overview

Journal Neurol Res Int

Publisher Wiley

Specialty Neurology

Date 2012 Oct 11

PMID 23050143

Citations 11

Authors

Edward A Shipton

Affiliations

Soon will be listed here.

Abstract

Movement disorders are neurological conditions affecting speed, fluency, quality, and ease of movement. Deep brain stimulation (DBS) is used to treat advanced Parkinson's disease, essential tremor, and dystonia. Possible target sites for DBS include the ventral intermediate nucleus of the thalamus, the globus pallidus internus, and the subthalamic nucleus. High-frequency DBS leads to a kind of functional deafferentation of the stimulated structure and to the modulation of cortical activity. This has a profound effect on the efficiency of movement. Indications for the use of DBS include the need to improve function, reduce medication dependency, and avoid ablative neurosurgery. Appropriate patient selection is critical for success. The implantation technique is briefly described. Programming stimulation parameters are performed via telemetry. The adverse effects of DBS are discussed. The future should see the development of "closed-loop" systems. Its use has promoted interdisciplinary team work and provided an improved understanding of the complex neurocircuitry associated with these disorders. DBS is a highly effective, safe, and reversible surgical treatment for advanced Parkinson's disease, tremor, and dystonia. It is a useful therapeutic option in carefully selected patients that significantly improves motor symptoms, functional status, and quality of life.

Citing Articles

Beyond Pallidal or Subthalamic Deep Brain Stimulation to Treat Dystonia.

Garg V, Srikar Lavu V, Hey G, Winter B, Firme M, Hilliard J Tremor Other Hyperkinet Mov (N Y). 2024; 14:45.

PMID: 39308988 PMC: 11414463. DOI: 10.5334/tohm.935.

Role of Diffusion Tensor Imaging in Early Diagnosis and Characterization of Movement Disorders.

Meyyappan M, Babu B, Anitha M, Ganesan G, S A, Natarajan P Cureus. 2024; 16(2):e53580.

PMID: 38449950 PMC: 10914641. DOI: 10.7759/cureus.53580.

Economic Evaluations Comparing Deep Brain Stimulation to Best Medical Therapy for Movement Disorders: A Meta-Analysis.

Lannon M, Duda T, Mastrolonardo A, Huang E, Martyniuk A, Farrokhyar F Pharmacoeconomics. 2023; 42(1):41-68.

PMID: 37751075 DOI: 10.1007/s40273-023-01318-y.

MRI findings in movement disorders and associated sleep disturbances.

Ghaderi S, Karami A, Ghalyanchi-Langeroudi A, Abdi N, Sharif Jalali S, Rezaei M Am J Nucl Med Mol Imaging. 2023; 13(3):77-94.

PMID: 37457325 PMC: 10349287.

Neuromodulation of cognition in Parkinson's disease.

Cole R, Okine D, Yeager B, Narayanan N Prog Brain Res. 2022; 269(1):435-455.

PMID: 35248205 PMC: 9199111. DOI: 10.1016/bs.pbr.2022.01.016.

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