Measurements of Location-Dependent Nitric Oxide Levels on Skin Surface in Relation to Acupuncture Point

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2012 Oct 11

PMID 23049611

Citations 10

Authors

Yejin Ha

Misun Kim

Jiseon Nah

Minah Suh

Youngmi Lee

Affiliations

Soon will be listed here.

Abstract

Location-dependent skin surface's partial nitric oxide pressure (pNO) is studied using highly sensitive amperometric NO microsensor with a small sensing area (diameter = 76 μm). The pNO level of LI4 (Hegu) acupuncture point is measured and compared with the pNO level of nonacupuncture point. In addition, the mapping of pNO is carried out over the left wrist skin area one- as well as two-dimensionally. Statistically higher pNO levels near the position of acupuncture points than non-acupuncture points are observed consistently, implying tight relationship between the level of NO release of skin and acupuncture points. The amperometric planar NO microsensor successfully monitors the heterogeneity of skin pNO distribution in high spatial resolution due to its advantageous features such as high sensitivity and small sensing dimension. The current study suggests the direct connection between NO and acupuncture points and possibly provides beneficial information to understand physiological roles and basis of the acupuncture points.

Citing Articles

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References

Lee M, Jeong S, Lee Y, Jeong D, Eo Y, Ko S . Differences in electrical conduction properties between meridians and non-meridians. Am J Chin Med. 2005; 33(5):723-8. DOI: 10.1142/S0192415X05003405. View

Faraci F . Role of nitric oxide in regulation of basilar artery tone in vivo. Am J Physiol. 1990; 259(4 Pt 2):H1216-21. DOI: 10.1152/ajpheart.1990.259.4.H1216. View

Zhang W, Tian Y, Zhu Z, Xu R . The distribution of transcutaneous CO2 emission and correlation with the points along the pericardium meridian. J Acupunct Meridian Stud. 2010; 2(3):197-201. DOI: 10.1016/S2005-2901(09)60055-8. View

Ma S, Li X, Sakurai T, Pandjaitan M . Evidence of enhanced non-enzymatic generation of nitric oxide on the skin surface of acupuncture points: An innovative approach in humans. Nitric Oxide. 2007; 17(2):60-8. DOI: 10.1016/j.niox.2007.05.004. View

Lee Y, Lee G, Park S, Jang A, Jhon G . Heterogeneity of skin oxygen density distribution: relation to location of acupuncture points. J Acupunct Meridian Stud. 2010; 2(4):269-72. DOI: 10.1016/S2005-2901(09)60067-4. View

Chan S . What is being stimulated in acupuncture: evaluation of the existence of a specific substrate. Neurosci Biobehav Rev. 1984; 8(1):25-33. DOI: 10.1016/0149-7634(84)90018-6. View

Sandberg M, Lundeberg T, Lindberg L, Gerdle B . Effects of acupuncture on skin and muscle blood flow in healthy subjects. Eur J Appl Physiol. 2003; 90(1-2):114-9. DOI: 10.1007/s00421-003-0825-3. View

Lee Y, Oh B, Meyerhoff M . Improved planar amperometric nitric oxide sensor based on platinized platinum anode. 1. Experimental results and theory when applied for monitoring NO release from diazeniumdiolate-doped polymeric films. Anal Chem. 2004; 76(3):536-44. DOI: 10.1021/ac035064h. View

Langevin H, Yandow J . Relationship of acupuncture points and meridians to connective tissue planes. Anat Rec. 2002; 269(6):257-65. DOI: 10.1002/ar.10185. View

10.

Beal M . Acupuncture and Oriental body work: traditional and biomedical concepts in holistic care: history and basic concepts. Holist Nurs Pract. 2002; 14(3):69-78. DOI: 10.1097/00004650-200004000-00011. View

11.

Ma W, Tong H, Xu W, Hu J, Liu N, Li H . Perivascular space: possible anatomical substrate for the meridian. J Altern Complement Med. 2004; 9(6):851-9. DOI: 10.1089/107555303771952208. View

12.

Ralt D . Intercellular communication, NO and the biology of Chinese medicine. Cell Commun Signal. 2005; 3(1):8. PMC: 1180462. DOI: 10.1186/1478-811X-3-8. View

13.

Ma S . Enhanced nitric oxide concentrations and expression of nitric oxide synthase in acupuncture points/meridians. J Altern Complement Med. 2003; 9(2):207-15. DOI: 10.1089/10755530360623329. View

14.

Johng H, Cho J, Shin H, Soh K, Koo T, Choi S . Frequency dependence of impedances at the acupuncture point Quze (PC3). IEEE Eng Med Biol Mag. 2002; 21(2):33-6. DOI: 10.1109/memb.2002.1000183. View

15.

Hong M, Park S, Ha Y, Lee J, Yoo K, Jhon G . Heterogeneity of skin surface oxygen level of wrist in relation to acupuncture point. Evid Based Complement Alternat Med. 2012; 2012:106762. PMC: 3362013. DOI: 10.1155/2012/106762. View