Urinary 6-sulfatoxymelatonin Level in Girls and Its Relationship with Obesity

Overview

Journal Korean J Pediatr

Specialty Pediatrics

Date 2012 Oct 11

PMID 23049592

Citations 4

Authors

Jieun Lee

Juyoung Yoon

Jin A Lee

Seong Yong Lee

Choong Ho Shin

Sei Won Yang

Affiliations

Soon will be listed here.

Abstract

Purpose: Short sleep duration is associated with obesity. Urinary 6-sulfatoxymelatonin (6-OHMS), the principal metabolite of melatonin, is closely related with sleep. We evaluated the difference in urinary 6-OHMS levels between obese girls and normal weight girls, and the relationship of urinary 6-OHMS with other hormones regulating body weight and metabolism.

Methods: A total of 79 girls (6.3 to 12.4 years) were included in this study, of whom 34 were obese; 15, overweight; and 30, normal-weight. We examined their pubertal status and bone age. Fasting serum levels of total ghrelin, leptin, insulin, and first morning urinary 6-OHMS were measured. Homeostatic model assessment-insulin resistance (HOMA-IR) was calculated from the fasting insulin and glucose levels.

Results: There was no significant difference in the creatinine adjusted 6-OHMS levels between the obese girls and the control group. Urinary 6-OHMS did not show any correlations with body mass index (BMI), BMI percentile, total ghrelin, leptin, and HOMA-IR. Negative correlations were found between urinary 6-OHMS levels and chronological and bone ages.

Conclusion: Our results suggest that melatonin production is not reduced consistently in obese girls.

Citing Articles

Interactions between nocturnal melatonin secretion, metabolism, and sleeping behavior in adolescents with obesity.

Overberg J, Kalveram L, Keller T, Krude H, Kuhnen P, Wiegand S Int J Obes (Lond). 2022; 46(5):1051-1058.

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Maternal Serum Melatonin Increases During Pregnancy and Falls Immediately After Delivery Implicating the Placenta as a Major Source of Melatonin.

Ejaz H, Figaro J, Woolner A, Thottakam B, Galley H Front Endocrinol (Lausanne). 2021; 11:623038.

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The effects of sleep and light at night on melatonin in adolescents.

Hersh C, Sisti J, Richiutti V, Schernhammer E Hormones (Athens). 2015; 14(3):399-409.

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Evaluation of serum xenin and ghrelin levels and their relationship with nonalcoholic fatty liver disease and insulin resistance in obese adolescents.

Arslan N, Sayin O, Tokgoz Y J Endocrinol Invest. 2014; 37(11):1091-7.

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References

Brydon L, Petit L, Delagrange P, Strosberg A, Jockers R . Functional expression of MT2 (Mel1b) melatonin receptors in human PAZ6 adipocytes. Endocrinology. 2001; 142(10):4264-71. DOI: 10.1210/endo.142.10.8423. View

Canpolat S, Aydin M, Yasar A, Colakoglu N, Yilmaz B, Kelestimur H . Effects of pinealectomy and exogenous melatonin on immunohistochemical ghrelin staining of arcuate nucleus and serum ghrelin leves in the rat. Neurosci Lett. 2006; 410(2):132-6. DOI: 10.1016/j.neulet.2006.09.071. View

Oba S, Nakamura K, Sahashi Y, Hattori A, Nagata C . Consumption of vegetables alters morning urinary 6-sulfatoxymelatonin concentration. J Pineal Res. 2008; 45(1):17-23. DOI: 10.1111/j.1600-079X.2007.00549.x. View

Diethelm K, Libuda L, Bolzenius K, Griefahn B, Buyken A, Remer T . Longitudinal associations between endogenous melatonin production and reported sleep duration from childhood to early adulthood. Horm Res Paediatr. 2010; 74(6):390-8. DOI: 10.1159/000303134. View

Prunet-Marcassus B, Desbazeille M, Bros A, Louche K, Delagrange P, Renard P . Melatonin reduces body weight gain in Sprague Dawley rats with diet-induced obesity. Endocrinology. 2003; 144(12):5347-52. DOI: 10.1210/en.2003-0693. View

Nogueira T, Lellis-Santos C, Jesus D, Taneda M, Rodrigues S, Amaral F . Absence of melatonin induces night-time hepatic insulin resistance and increased gluconeogenesis due to stimulation of nocturnal unfolded protein response. Endocrinology. 2011; 152(4):1253-63. DOI: 10.1210/en.2010-1088. View

Robeva R, Kirilov G, Tomova A, Kumanov P . Melatonin-insulin interactions in patients with metabolic syndrome. J Pineal Res. 2007; 44(1):52-6. DOI: 10.1111/j.1600-079X.2007.00527.x. View

Schmidt F, Penka B, Trauner M, Reinsperger L, Ranner G, Ebner F . Lack of pineal growth during childhood. J Clin Endocrinol Metab. 1995; 80(4):1221-5. DOI: 10.1210/jcem.80.4.7536203. View

Gitto E, Aversa S, Reiter R, Barberi I, Pellegrino S . Update on the use of melatonin in pediatrics. J Pineal Res. 2010; 50(1):21-8. DOI: 10.1111/j.1600-079X.2010.00814.x. View

10.

Contreras-Alcantara S, Baba K, Tosini G . Removal of melatonin receptor type 1 induces insulin resistance in the mouse. Obesity (Silver Spring). 2010; 18(9):1861-3. PMC: 2929321. DOI: 10.1038/oby.2010.24. View

11.

Alonso-Vale M, Peres S, Vernochet C, Farmer S, Lima F . Adipocyte differentiation is inhibited by melatonin through the regulation of C/EBPbeta transcriptional activity. J Pineal Res. 2009; 47(3):221-7. DOI: 10.1111/j.1600-079X.2009.00705.x. View

12.

Fideleff H, Boquete H, Fideleff G, Albornoz L, Perez Lloret S, Suarez M . Gender-related differences in urinary 6-sulfatoxymelatonin levels in obese pubertal individuals. J Pineal Res. 2006; 40(3):214-8. DOI: 10.1111/j.1600-079X.2005.00301.x. View

13.

Wolden-Hanson T, Mitton D, McCants R, Yellon S, Wilkinson C, Matsumoto A . Daily melatonin administration to middle-aged male rats suppresses body weight, intraabdominal adiposity, and plasma leptin and insulin independent of food intake and total body fat. Endocrinology. 2000; 141(2):487-97. DOI: 10.1210/endo.141.2.7311. View

14.

Hasler G, Buysse D, Klaghofer R, Gamma A, Ajdacic V, Eich D . The association between short sleep duration and obesity in young adults: a 13-year prospective study. Sleep. 2004; 27(4):661-6. DOI: 10.1093/sleep/27.4.661. View

15.

Gangwisch J, Malaspina D, Boden-Albala B, Heymsfield S . Inadequate sleep as a risk factor for obesity: analyses of the NHANES I. Sleep. 2005; 28(10):1289-96. DOI: 10.1093/sleep/28.10.1289. View

16.

Pan M, Song Y, Xu J, Gan H . Melatonin ameliorates nonalcoholic fatty liver induced by high-fat diet in rats. J Pineal Res. 2006; 41(1):79-84. DOI: 10.1111/j.1600-079X.2006.00346.x. View

17.

Cook M, Graham C, Kavet R, Stevens R, Davis S, Kheifets L . Morning urinary assessment of nocturnal melatonin secretion in older women. J Pineal Res. 2000; 28(1):41-7. DOI: 10.1034/j.1600-079x.2000.280106.x. View

18.

Agil A, Navarro-Alarcon M, Ruiz R, Abuhamadah S, El-Mir M, Fernandez Vazquez G . Beneficial effects of melatonin on obesity and lipid profile in young Zucker diabetic fatty rats. J Pineal Res. 2010; 50(2):207-12. DOI: 10.1111/j.1600-079X.2010.00830.x. View

19.

Aydin M, Canpolat S, Kuloglu T, Yasar A, Colakoglu N, Kelestimur H . Effects of pinealectomy and exogenous melatonin on ghrelin and peptide YY in gastrointestinal system and neuropeptide Y in hypothalamic arcuate nucleus: immunohistochemical studies in male rats. Regul Pept. 2007; 146(1-3):197-203. DOI: 10.1016/j.regpep.2007.09.009. View

20.

Kozirog M, Poliwczak A, Duchnowicz P, Koter-Michalak M, Sikora J, Broncel M . Melatonin treatment improves blood pressure, lipid profile, and parameters of oxidative stress in patients with metabolic syndrome. J Pineal Res. 2010; 50(3):261-6. DOI: 10.1111/j.1600-079X.2010.00835.x. View