» Articles » PMID: 23046647

Iron Transport Machinery of Human Cells: Players and Their Interactions

Overview
Journal Curr Top Membr
Date 2012 Oct 11
PMID 23046647
Citations 19
Authors
Affiliations
Soon will be listed here.
Abstract

Organisms, like cells, maintain tight control of iron. In humans as well as other mammals, control is achieved through the regulation of iron uptake into the body rather than through the excretion of iron. The mechanisms by which humans and mice regulate both iron uptake and the distribution of iron within the body and cells are reviewed. Special emphasis is given to the iron transporters involved in this process.

Citing Articles

Orthogonal Versatile Interacting Peptide Tags for Imaging Cellular Proteins.

Suyama A, Devlin K, Macias-Contreras M, Doh J, Shinde U, Beatty K Biochemistry. 2023; 62(11):1735-1743.

PMID: 37167569 PMC: 10249344. DOI: 10.1021/acs.biochem.2c00712.


Spatial-temporal changes of iron deposition and iron metabolism after traumatic brain injury in mice.

Cheng H, Wang N, Ma X, Wang P, Dong W, Chen Z Front Mol Neurosci. 2022; 15:949573.

PMID: 36034497 PMC: 9405185. DOI: 10.3389/fnmol.2022.949573.


Ins and Outs: Recent Advancements in Membrane Protein-Mediated Prokaryotic Ferrous Iron Transport.

Brown J, Lee M, Smith A Biochemistry. 2021; 60(44):3277-3291.

PMID: 34670078 PMC: 8979593. DOI: 10.1021/acs.biochem.1c00586.


Of mitochondrion and COVID-19.

Alfarouk K, Alhoufie S, Hifny A, Schwartz L, Alqahtani A, B M Ahmed S J Enzyme Inhib Med Chem. 2021; 36(1):1258-1267.

PMID: 34107824 PMC: 8205080. DOI: 10.1080/14756366.2021.1937144.


Ferrotoxicity and Its Amelioration by Calcitriol in Cultured Renal Cells.

Annamalai C, Seth R, Viswanathan P Anal Cell Pathol (Amst). 2021; 2021:6634429.

PMID: 33680716 PMC: 7925041. DOI: 10.1155/2021/6634429.


References
1.
De Domenico I, Lo E, Yang B, Korolnek T, Hamza I, Ward D . The role of ubiquitination in hepcidin-independent and hepcidin-dependent degradation of ferroportin. Cell Metab. 2011; 14(5):635-46. PMC: 3229915. DOI: 10.1016/j.cmet.2011.09.008. View

2.
Knutson M, Wessling-Resnick M . Iron metabolism in the reticuloendothelial system. Crit Rev Biochem Mol Biol. 2003; 38(1):61-88. DOI: 10.1080/713609210. View

3.
Yamashiro D, Tycko B, Fluss S, Maxfield F . Segregation of transferrin to a mildly acidic (pH 6.5) para-Golgi compartment in the recycling pathway. Cell. 1984; 37(3):789-800. DOI: 10.1016/0092-8674(84)90414-8. View

4.
Aruoma O, Halliwell B, Laughton M, Quinlan G, Gutteridge J . The mechanism of initiation of lipid peroxidation. Evidence against a requirement for an iron(II)-iron(III) complex. Biochem J. 1989; 258(2):617-20. PMC: 1138407. DOI: 10.1042/bj2580617. View

5.
Shindo M, Torimoto Y, Saito H, Motomura W, Ikuta K, Sato K . Functional role of DMT1 in transferrin-independent iron uptake by human hepatocyte and hepatocellular carcinoma cell, HLF. Hepatol Res. 2006; 35(3):152-62. DOI: 10.1016/j.hepres.2006.03.011. View