Parotid Gland Atrophy in Patients with Chronic Trigeminal Nerve Denervation

Overview

Journal AJNR Am J Neuroradiol

Specialty Neurology

Date 2012 Oct 9

PMID 23042921

Citations 4

Authors

E Raz

L Saba

M Hagiwara

L C Hygino de Cruz Jr

P M Som

G M Fatterpekar

Affiliations

Soon will be listed here.

Abstract

Background And Purpose: Trigeminal nerve injury or dysfunction is associated with denervation atrophy of muscles innervated by the mandibular branch of the trigeminal nerve. The purpose of our study was to evaluate the association between chronic CN V denervation and parotid gland atrophy.

Materials And Methods: Twenty-six patients with chronic masticator muscle atrophy were retrospectively identified and evaluated for the presence of ipsilateral parotid gland atrophy. Twenty-six age-matched control subjects with no clinical or imaging evidence of chronic masticator space atrophy were also identified. Segmentation of the parotid gland was performed to calculate a parotid asymmetry index. The Fisher exact test and t test were respectively used to determine the correlation between parotid gland atrophy and ipsilateral masticator muscle atrophy and to evaluate any difference in the size of the involved parotid gland when compared with that in the control subjects.

Results: Ipsilateral parotid gland atrophy was seen in 9/26 (42.8%) patients with fatty replacement of the masticator group of muscles, suggesting a correlation between parotid gland atrophy and CN V denervation (P<.001). The parotid asymmetry index was significantly different in patients with CN V denervation (0.59±0.25) compared with control subjects (0.92±0.03) (P<.001).

Conclusions: Ipsilateral parotid gland atrophy can accompany chronic CN V denervation change, and its clinical significance remains to be determined.

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References

Dodds M, Johnson D, Yeh C . Health benefits of saliva: a review. J Dent. 2005; 33(3):223-33. DOI: 10.1016/j.jdent.2004.10.009. View

Markitziu A, Reches A . Oro-facial trophic changes induced by nerve injury. Int J Oral Surg. 1982; 11(1):69-72. DOI: 10.1016/s0300-9785(82)80052-5. View

Hector M, Linden R . The possible role of periodontal mechanoreceptors in the control of parotid secretion in man. Q J Exp Physiol. 1987; 72(3):285-301. DOI: 10.1113/expphysiol.1987.sp003075. View

Khosravani N, Ekman R, Ekstrom J . The peptidergic innervation of the rat parotid gland: effects of section of the auriculo-temporal nerve and/or of otic ganglionectomy. Arch Oral Biol. 2007; 53(3):238-42. DOI: 10.1016/j.archoralbio.2007.09.008. View

EMMELIN N . Degeneration secretion from parotid glands after section of the auriculotemporal nerves at different levels. J Physiol. 1968; 195(2):407-18. PMC: 1351670. DOI: 10.1113/jphysiol.1968.sp008465. View

Smoker W, Reede D . Denervation atrophy of motor cranial nerves. Neuroimaging Clin N Am. 2008; 18(2):387-411, xi. DOI: 10.1016/j.nic.2007.12.011. View

RUSSO C, Smoker W, Weissman J . MR appearance of trigeminal and hypoglossal motor denervation. AJNR Am J Neuroradiol. 1997; 18(7):1375-83. PMC: 8338018. View

Anderson D, Hector M, Linden R . The effects of unilateral and bilateral chewing, empty clenching and simulated bruxism, on the masticatory-parotid salivary reflex in man. Exp Physiol. 1996; 81(2):305-12. DOI: 10.1113/expphysiol.1996.sp003934. View

Scott B, Hassanwalia R, Linden R . The masticatory-parotid salivary reflex in edentulous subjects. J Oral Rehabil. 1998; 25(1):28-33. DOI: 10.1046/j.1365-2842.1998.00203.x. View

10.

Wolff A, Ofer S, Raviv M, Helft M, Cardash H . The flow rate of whole and submandibular/sublingual gland saliva in patients receiving replacement complete dentures. J Oral Rehabil. 2004; 31(4):340-3. DOI: 10.1046/j.1365-2842.2003.01247.x. View

11.

Mandour M, Helmi A, El-Sheikh M, el-Ghazzawi E . Effect of tympanic neurectomy on human parotid salivary gland. Histopathologic, Histochemical, and Clinical Study. Arch Otolaryngol. 1977; 103(6):338-41. DOI: 10.1001/archotol.1977.00780230060008. View

12.

Sharkey K, Templeton D . Substance P in the rat parotid gland: evidence for a dual origin from the otic and trigeminal ganglia. Brain Res. 1984; 304(2):392-6. DOI: 10.1016/0006-8993(84)90346-9. View

13.

Jensen Kjeilen J, Brodin P, AARS H, Berg T . Parotid salivary flow in response to mechanical and gustatory stimulation in man. Acta Physiol Scand. 1987; 131(2):169-75. DOI: 10.1111/j.1748-1716.1987.tb08223.x. View

14.

Du Toit D . Auriculo-temporal nerve. Clinicopathological relevance to facial-maxillary practice. SADJ. 2003; 58(2):62-3. View

15.

Porto Jr A, PROUD G, Norris C, Odoi H . Secretory innervation of the parotid gland. Otolaryngol Head Neck Surg. 1981; 89(1):16-9. DOI: 10.1177/019459988108900104. View

16.

Kawasaka T, Shimodozono M, Ogata A, Tanaka N, Kawahira K . Salivary secretion and occlusal force in patients with unilateral cerebral stroke. Int J Neurosci. 2010; 120(5):355-60. DOI: 10.3109/00207450802338754. View