Molecular and Biological Role of the FOXP3 N-terminal Domain in Immune Regulation by T Regulatory/suppressor Cells

Overview

Journal Exp Mol Pathol

Publisher Elsevier

Specialties Molecular Biology
Pathology

Date 2012 Oct 9

PMID 23041265

Citations 16

Authors

Guoping Deng

Yan Xiao

Zhaocai Zhou

Yasuhiro Nagai

Hongtao Zhang

Bin Li

Mark I Greene

Affiliations

Soon will be listed here.

Abstract

Regulatory T (Treg) cells are essential in preventing the host from developing certain autoimmune diseases and limiting excessive immune responses against pathogens. The normal function of most Treg cells requires sustained expression of functional FOXP3, a member of the FOXP family transcription factors. FOXP3 is distinct from other subfamily members because of its unique proline rich amino (N)-terminal domain. Mutations in this region are occasionally identified in certain patients with X-linked autoimmunity-allergic dysregulation syndrome (XLAAD) and similar mutations also increase susceptibility of autoimmune diseases in rodent models. Previous analyses of the FOXP3 N-terminal domain revealed a role in nuclear import, interaction with other transcription factors, and as sites of specific post-translational modifications of FOXP3 that contribute to FOXP3 stability.

Citing Articles

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A Structure-Guided Delineation of FOXP3 Regulation Mechanism in IPEX.

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