Coexisting Malignant Melanoma and Blue Nevus of the Uterine Cervix: an Unusual Combination

Overview

Journal Case Rep Pathol

Publisher Wiley

Specialty Pathology

Date 2012 Oct 2

PMID 23024873

Citations 4

Authors

David Parada

Karla B Pena

Frances Riu

Affiliations

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Abstract

Malignant melanoma (MM) and blue nevi of the uterine cervix are an extremely rare neoplasm, probably derived from embryologic migration of melanocytes from the neural crest. MM displays aggressive behavior with a poor prognosis. We report the case of a 76-year-old postmenopausal woman abnormal vaginal bleeding. She underwent a hysterectomy and bilateral salpingo-oophorectomy with paraaortic-iliac lymphadenectomy. Histopathological and immunohistochemical studies were consistent with the diagnosis of MM and blue nevi in the uterine cervix. Although it is extremely rare, this case suggests that MM of the uterine cervix should be considered in the differential diagnosis of undifferentiated neoplasm. Early diagnosis is essential in order to warrant a better prognosis, although there are no cases of cure described.

Citing Articles

Primary Melanoma of the Cervix Uteri: A Systematic Review and Meta-Analysis of the Reported Cases.

Kechagias K, Zafeiri M, Katsikas Triantafyllidis K, Kyrtsonis G, Geropoulos G, Lyons D Biology (Basel). 2023; 12(3).

PMID: 36979090 PMC: 10045237. DOI: 10.3390/biology12030398.

Primary Malignant Melanoma of the Cervix: An Integrated Analysis of Case Reports and Series.

Min A, Fu A, Huang M, Wang H, Chen H Front Oncol. 2022; 12:913964.

PMID: 35814437 PMC: 9258497. DOI: 10.3389/fonc.2022.913964.

Primary Malignant Melanoma of the Cervix: A Case Report and a Review of the Literature.

Diakosavvas M, Fasoulakis Z, Kouroupi M, Theodora M, Inagamova L, Tsatsaris G Case Rep Oncol Med. 2021; 2020:7206786.

PMID: 33628550 PMC: 7898279. DOI: 10.1155/2020/7206786.

Incidentally Detected Blue Nevus of Endocervix: a Case Report.

Bhat S, Shivamurthy A, Rao A Iran J Pathol. 2015; 10(3):248-52.

PMID: 26351493 PMC: 4539768.

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