Patched Knockout Mouse Models of Basal Cell Carcinoma

Overview

Journal J Skin Cancer

Publisher Wiley

Specialty Dermatology

Date 2012 Oct 2

PMID 23024864

Citations 18

Authors

Frauke Nitzki

Marco Becker

Anke Frommhold

Walter Schulz-Schaeffer

Heidi Hahn

Affiliations

Soon will be listed here.

Abstract

Basal cell carcinoma (BCC) is the most common human tumor. Mutations in the hedgehog (HH) receptor Patched (PTCH) are the main cause of BCC. Due to their high and increasing incidence, BCC are becoming all the more important for the health care system. Adequate animal models are required for the improvement of current treatment strategies. A good model should reflect the situation in humans (i.e., BCC initiation due to Ptch mutations on an immunocompetent background) and should allow for (i) BCC induction at a defined time point, (ii) analysis of defined BCC stages, and (iii) induction of BCC in 100% of animals. In addition, it should be easy to handle. Here, we compare several currently existing conventional and conditional Ptch knockout mouse models for BCC and their potential use in preclinical research. In addition, we provide new data using conditional Ptch(flox/flox) mice and the K5-Cre-ER(T+/-) driver.

Citing Articles

Modulation of Hedgehog Signaling for the Treatment of Basal Cell Carcinoma and the Development of Preclinical Models.

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Canonical Hedgehog Pathway and Noncanonical GLI Transcription Factor Activation in Cancer.

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Chemopreventive efficacy of silibinin against basal cell carcinoma growth and progression in UVB-irradiated Ptch+/- mice.

Paudel S, Raina K, Tiku V, Maurya A, Orlicky D, You Z Carcinogenesis. 2022; 43(6):557-570.

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Anti-PD-1 Therapy with Adjuvant Ablative Fractional Laser Improves Anti-Tumor Response in Basal Cell Carcinomas.

Olesen U, Wiinberg M, Lerche C, Jaehger D, Andresen T, Haedersdal M Cancers (Basel). 2021; 13(24).

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Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas.

Wan J, Dai H, Zhang X, Liu S, Lin Y, Somani A Genes Dis. 2021; 8(2):181-192.

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