Highly Enantioselective [4 + 2] Cyclization of Chloroaldehydes and 1-azadienes Catalyzed by N-heterocyclic Carbenes

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2012 Oct 2

PMID 23023792

Citations 6

Authors

Teng-Yue Jian

Li-Hui Sun

Song Ye

Affiliations

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Abstract

Highly functionalized dihydropyridinones were synthesized via the N-heterocyclic carbene-catalyzed enantioselective [4 + 2] annulation of α-chloroaldehydes and azadienes. Hydrogenation of the resulted dihydropyridinones afforded the corresponding piperidinones with high enantiopurity.

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