BODIPY Dyes in Photodynamic Therapy

Overview

Journal Chem Soc Rev

Specialty Chemistry

Date 2012 Sep 28

PMID 23014776

Citations 246

Authors

Anyanee Kamkaew

Siang Hui Lim

Hong Boon Lee

Lik Voon Kiew

Lip Yong Chung

Kevin Burgess

Affiliations

Soon will be listed here.

Abstract

BODIPY dyes tend to be highly fluorescent, but their emissions can be attenuated by adding substituents with appropriate oxidation potentials. Substituents like these have electrons to feed into photoexcited BODIPYs, quenching their fluorescence, thereby generating relatively long-lived triplet states. Singlet oxygen is formed when these triplet states interact with (3)O(2). In tissues, this causes cell damage in regions that are illuminated, and this is the basis of photodynamic therapy (PDT). The PDT agents that are currently approved for clinical use do not feature BODIPYs, but there are many reasons to believe that this situation will change. This review summarizes the attributes of BODIPY dyes for PDT, and in some related areas.

Citing Articles

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PMID: 40068139 PMC: 11896635. DOI: 10.1002/jcc.70026.

Novel BODIPY Dyes with a -Benzoxadiazole Substituent: Synthesis, Photophysical Studies, and Cytotoxic Activity Under Normoxic and Hypoxic Conditions.

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