Kiss of the Mutant Mouse: How Genetically Altered Mice Advanced Our Understanding of Kisspeptin's Role in Reproductive Physiology

Overview

Journal Endocrinology

Publisher Oxford University Press

Specialty Endocrinology

Date 2012 Sep 27

PMID 23011921

Citations 5

Authors

Heather M Dungan Lemko

Carol F Elias

Affiliations

Soon will be listed here.

Abstract

The kisspeptin system has emerged as one of the most important circuits within the central network governing reproduction. Although kisspeptin physiology has been examined in many species, much of our understanding of this system has come from mice. Recently, the study of several innovative strains of genetically engineered mouse models has revealed intriguing and unexpected insights into the functions of kisspeptin signaling in the hypothalamus. Here, we review the advancements in our knowledge of the central kisspeptin system through the use of mutant mice.

Citing Articles

Expression of genes for Kisspeptin (KISS1), Neurokinin B (TAC3), Prodynorphin (PDYN), and gonadotropin inhibitory hormone (RFRP) across natural puberty in ewes.

Li Q, Smith J, Henry B, Rao A, Pereira A, Clarke I Physiol Rep. 2020; 8(5):e14399.

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High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes.

Brommage R, Liu J, Hansen G, Kirkpatrick L, Potter D, Sands A Bone Res. 2015; 2:14034.

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Estradiol Membrane-Initiated Signaling and Female Reproduction.

Micevych P, Wong A, Mittelman-Smith M Compr Physiol. 2015; 5(3):1211-22.

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Impaired GABAB receptor signaling dramatically up-regulates Kiss1 expression selectively in nonhypothalamic brain regions of adult but not prepubertal mice.

Di Giorgio N, Semaan S, Kim J, Lopez P, Bettler B, Libertun C Endocrinology. 2014; 155(3):1033-44.

PMID: 24424047 PMC: 3929734. DOI: 10.1210/en.2013-1573.

Neuroanatomy of the kisspeptin signaling system in mammals: comparative and developmental aspects.

Lehman M, Hileman S, Goodman R Adv Exp Med Biol. 2013; 784:27-62.

PMID: 23550001 PMC: 4059209. DOI: 10.1007/978-1-4614-6199-9_3.

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