Hepatitis Types A, B, and Non A--non B in Childhood

Overview

Journal Eur J Pediatr

Specialty Pediatrics

Date 1979 Jan 1

PMID 230049

Citations 1

Authors

C Franzen

M Brodersen

G Frosner

J STRODER

D Wiebecke

Affiliations

Soon will be listed here.

Abstract

199 children with acute hepatitis hospitalized between 1968 and 1978 were tested for serological markers of hepatitis A and B infection. In 24 out of 28 HBsAg-positive patients, hepatitis B infection was diagnosed because of the disappearance of the antigen during convalescence. The histories of the 171 HBsAg-negative children suggested acute hepatitis A infection in 69% of the patients. This diagnosis could be confirmed in 110 of the 116 tested cases (95%) by a more than fourfold increase in the anti-HAV titer or by detection of anti-HAV of the IgM class. In the 55 HBsAg-negative patients without epidemiological clues as to the type of hepatitis, 40 children exhibited anti-HAV which could be related to acute A infection in 21 out of 22 tested cases. At least 11 patients had to be classified as having nonn A--non B infection. The results indicate that a combination of evaluation of the patient's history and selected serological tests will permit a fast preliminary diagnosis. This is important in the clinical management of patients and protection of contacts with immunoglobulin.

Citing Articles

Viral hepatitis in Danish children. Disappearance of an infection from its previous reservoir.

Skinhoj P, Ibsen K, Kryger P Arch Dis Child. 1982; 57(2):146-8.

PMID: 7065711 PMC: 1627532. DOI: 10.1136/adc.57.2.146.

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