CPhos: a Program to Calculate and Visualize Evolutionarily Conserved Functional Phosphorylation Sites

Overview

Journal Proteomics

Date 2012 Sep 25

PMID 23001821

Citations 17

Authors

Boyang Zhao

Trairak Pisitkun

Jason D Hoffert

Mark A Knepper

Fahad Saeed

Affiliations

Soon will be listed here.

Abstract

Profiling using high-throughput MS has discovered an overwhelming number of novel protein phosphorylation sites ("phosphosites"). However, the functional relevance of these sites is not always clear. In light of recent studies on the evolutionary mechanism of phosphorylation, we have developed CPhos, a Java program that can assess the conservation of phosphosites among species using an information theory-based approach. The degree of conservation established using CPhos can be used to assess the functional significance of phosphosites. CPhos has a user friendly graphical user interface and is available both as a web service and as a standalone Java application to assist phosphoproteomic researchers in analyzing and prioritizing lists of phosphosites for further experimental validation. CPhos can be accessed or downloaded at http://helixweb.nih.gov/CPhos/.

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