Reinventing Primaquine for Endemic Malaria

Overview

Journal Expert Opin Emerg Drugs

Date 2012 Sep 25

PMID 22998791

Citations 13

Authors

John Kevin Baird

Affiliations

Soon will be listed here.

Abstract

After sixty years of continuous use, primaquine remains the only therapy licensed for arresting transmission and relapse of malaria. The US Army developed primaquine for soldiers in a wartime crisis setting. Dosing strategies suited to that narrow population were adopted without modification or validation for the broader population of humans exposed to risk of malaria. The poor suitability of these strategies in populations exhibiting greater vulnerability to hemolytic toxicity among glucose-6-phosphate dehydrogenase deficient patients has not been addressed. Primaquine requires chemotherapeutic reinvention delivering less threatening doses by leveraging unexplored co-drug synergies.

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References

Burgoine K, Bancone G, Nosten F . The reality of using primaquine. Malar J. 2010; 9:376. PMC: 3018394. DOI: 10.1186/1475-2875-9-376. View

Marks P, Gross R . Erythrocyte glucose-6-phosphate dehydrogenase deficiency: evidence of differences between Negroes and Caucasians with respect to this genetically determined trait. J Clin Invest. 1959; 38:2253-62. PMC: 293318. DOI: 10.1172/JCI104006. View

Rieckmann K, McNamara J, Kass L, Powell R . Gametocytocidal and sporontocidal effects of primaquine upon two strains of Plasmodium falciparum. Mil Med. 1969; 134(10):802-19. View

ALVING A, Johnson C, TARLOV A, Brewer G, KELLERMEYER R, Carson P . Mitigation of the haemolytic effect of primaquine and enhancement of its action against exoerythrocytic forms of the Chesson strain of Piasmodium vivax by intermittent regimens of drug administration: a preliminary report. Bull World Health Organ. 1960; 22:621-31. PMC: 2555355. View

Baird J . Elimination therapy for the endemic malarias. Curr Infect Dis Rep. 2012; 14(3):227-37. PMC: 3342493. DOI: 10.1007/s11908-012-0250-z. View

Ziai M, Amirhakimi G, REINHOLD J, Tabatabee M, Gettner M, Bowman J . Malaria prophylaxis and treatment in G-6-PD deficiency. An observation on the toxicity of primaquine and chloroquine. Clin Pediatr (Phila). 1967; 6(4):242-3. DOI: 10.1177/000992286700600416. View

SHANNON J . Chemotherapy in malaria. Bull N Y Acad Med. 2010; 22:345-57. View

Neill U . From branch to bedside: Youyou Tu is awarded the 2011 Lasker~DeBakey Clinical Medical Research Award for discovering artemisinin as a treatment for malaria. J Clin Invest. 2011; 121(10):3768-73. PMC: 3195493. DOI: 10.1172/jci60887. View

Reeve P, Toaliu H, Kaneko A, Hall J, Ganczakowski M . Acute intravascular haemolysis in Vanuatu following a single dose of primaquine in individuals with glucose-6-phosphate dehydrogenase deficiency. J Trop Med Hyg. 1992; 95(5):349-51. View

10.

Cappellini M, Fiorelli G . Glucose-6-phosphate dehydrogenase deficiency. Lancet. 2008; 371(9606):64-74. DOI: 10.1016/S0140-6736(08)60073-2. View

11.

ALVING A, Arnold J, HOCKWALD R, CLAYMAN C, DERN R, Beutler E . Potentiation of the curative action of primaquine in vivax malaria by quinine and chloroquine. J Lab Clin Med. 1955; 46(2):301-6. View

12.

SALVIDIO E, PANNACCIULLI I, Tizianello A, Ajmar F . Nature of hemolytic crises and the fate of G6PD deficient, drug-damaged erythrocytes in Sardinians. N Engl J Med. 1967; 276(24):1339-44. DOI: 10.1056/NEJM196706152762402. View

13.

Baird J, Surjadjaja C . Consideration of ethics in primaquine therapy against malaria transmission. Trends Parasitol. 2010; 27(1):11-6. DOI: 10.1016/j.pt.2010.08.005. View

14.

Beutler E . Glucose-6-phosphate dehydrogenase deficiency: a historical perspective. Blood. 2007; 111(1):16-24. DOI: 10.1182/blood-2007-04-077412. View

15.

CLYDE D . Clinical problems associated with the use of primaquine as a tissue schizontocidal and gametocytocidal drug. Bull World Health Organ. 1981; 59(3):391-5. PMC: 2396064. View

16.

Rieckmann K, McNamara J, FRISCHER H, Stockert T, Carson P, Powell R . Gametocytocidal and sporontocidal effects of primaquine and of sulfadiazine with pyrimethamine in a chloroquine-resistant strain of Plasmodium falciparum. Bull World Health Organ. 1968; 38(4):625-32. PMC: 2554527. View

17.

BARRETT Jr O, Skrzypek G, Datel W, GOLDSTEIN J . Malaria imported to the United States from Vietnam. Chemoprophylaxis evaluated in returning soldiers. Am J Trop Med Hyg. 1969; 18(4):495-9. DOI: 10.4269/ajtmh.1969.18.495. View

18.

George J, Sears D, McCurdy P, CONRAD M . Primaquine sensitivity in Caucasians: hemolytic reactions induced by primaquine in G-6-PD deficient subjects. J Lab Clin Med. 1967; 70(1):80-93. View

19.

Nasveld P, Edstein M, Reid M, Brennan L, Harris I, Kitchener S . Randomized, double-blind study of the safety, tolerability, and efficacy of tafenoquine versus mefloquine for malaria prophylaxis in nonimmune subjects. Antimicrob Agents Chemother. 2009; 54(2):792-8. PMC: 2812156. DOI: 10.1128/AAC.00354-09. View

20.

Schmidt L . Enhancement of the curative activity of primaquine by concomitant administration of mirincamycin. Antimicrob Agents Chemother. 1985; 27(2):151-7. PMC: 176228. DOI: 10.1128/AAC.27.2.151. View