In Vitro Antioxidant Activity Potential of Lantadene A, a Pentacyclic Triterpenoid of Lantana Plants

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2012 Sep 21

PMID 22992785

Citations 10

Authors

Chong Grace-Lynn

Ibrahim Darah

Yeng Chen

Lachimanan Yoga Latha

Subramanion L Jothy

Sreenivasan Sasidharan

Affiliations

Soon will be listed here.

Abstract

Lantadenes are pentacyclic triterpenoids present in the leaves of the plant Lantana camara. In the present study, in vitro antioxidant activity and free radical scavenging capacity of lantadene A was evaluated using established in vitro models such as ferric reducing antioxidant power (FRAP), 2,2-diphenyl-1-picryl-hydrazyl (DPPH•), hydroxyl radical (OH•), nitric oxide radical (NO•), superoxide anion scavenging activities and ferrous ion chelating assay. Interestingly, lantadene A showed considerable in vitro antioxidant, free radical scavenging capacity activities in a dose dependant manner when compared with the standard antioxidant in nitric oxide scavenging, superoxide anion radical scavenging and ferrous ion chelating assay. These findings show that the lantadene A possesses antioxidant activity with different mechanism of actions towards the different free radicals tested. Since lantadene A is a very popular drug in modern medicine, it is a promising candidate for use as an antioxidant and hepatoprotective agent.

Citing Articles

Ethnobotany, Phytochemistry, and Biological Activity of Extracts and Non-Volatile Compounds from L. and Semisynthetic Derivatives-An Updated Review.

Ramirez J, Armijos C, Espinosa-Ortega N, Castillo L, Vidari G Molecules. 2025; 30(4).

PMID: 40005162 PMC: 11858648. DOI: 10.3390/molecules30040851.

From an Invasive Weed to an Insecticidal Agent: Exploring the Potential of in Insect Management Strategies-A Review.

Kumar R, Guleria N, Deeksha M, Kumari N, Kumar R, Jha A Int J Mol Sci. 2024; 25(23).

PMID: 39684506 PMC: 11641641. DOI: 10.3390/ijms252312788.

Phyto-pharmacological and computational profiling of Linn. Leaves revealed pharmacological properties against oxidation, hyperglycemia, pain, and diarrhea.

Taher M, Hossain M, Zahan M, Hasan M, Ferdous J, Rahman A Heliyon. 2024; 10(15):e35422.

PMID: 39170236 PMC: 11336592. DOI: 10.1016/j.heliyon.2024.e35422.

Antidiabetic and hypolipidemic activities of eburicoic acid, a triterpenoid compound from , by regulation of Akt phosphorylation, gluconeogenesis, and PPARα in streptozotocin-induced diabetic mice.

Lin C, Kuo Y, Shih C RSC Adv. 2022; 8(37):20462-20476.

PMID: 35542324 PMC: 9080793. DOI: 10.1039/c8ra01841c.

Animal Models of Inflammation for Screening of Anti-inflammatory Drugs: Implications for the Discovery and Development of Phytopharmaceuticals.

Patil K, Mahajan U, Unger B, Goyal S, Belemkar S, Surana S Int J Mol Sci. 2019; 20(18).

PMID: 31491986 PMC: 6770891. DOI: 10.3390/ijms20184367.

References

Shimada T, Watanabe N, Ohtsuka Y, Endoh M, Kojima K, Hiraishi H . Polaprezinc down-regulates proinflammatory cytokine-induced nuclear factor-kappaB activiation and interleukin-8 expression in gastric epithelial cells. J Pharmacol Exp Ther. 1999; 291(1):345-52. View

Otuki M, Ferreira J, Lima F, Meyre-Silva C, Malheiros A, Muller L . Antinociceptive properties of mixture of alpha-amyrin and beta-amyrin triterpenes: evidence for participation of protein kinase C and protein kinase A pathways. J Pharmacol Exp Ther. 2005; 313(1):310-8. DOI: 10.1124/jpet.104.071779. View

Halliwell B, Gutteridge J, Aruoma O . The deoxyribose method: a simple "test-tube" assay for determination of rate constants for reactions of hydroxyl radicals. Anal Biochem. 1987; 165(1):215-9. DOI: 10.1016/0003-2697(87)90222-3. View

Pass M . Current ideas on the pathophysiology and treatment of lantana poisoning of ruminants. Aust Vet J. 1986; 63(6):169-71. DOI: 10.1111/j.1751-0813.1986.tb02965.x. View

Halliwell B, Chirico S . Lipid peroxidation: its mechanism, measurement, and significance. Am J Clin Nutr. 1993; 57(5 Suppl):715S-724S; discussion 724S-725S. DOI: 10.1093/ajcn/57.5.715S. View

Shinar E, Rachmilewitz E . Oxidative denaturation of red blood cells in thalassemia. Semin Hematol. 1990; 27(1):70-82. View

Dinis T, Maderia V, Almeida L . Action of phenolic derivatives (acetaminophen, salicylate, and 5-aminosalicylate) as inhibitors of membrane lipid peroxidation and as peroxyl radical scavengers. Arch Biochem Biophys. 1994; 315(1):161-9. DOI: 10.1006/abbi.1994.1485. View

Wink D, Kasprzak K, Maragos C, Elespuru R, Misra M, Dunams T . DNA deaminating ability and genotoxicity of nitric oxide and its progenitors. Science. 1991; 254(5034):1001-3. DOI: 10.1126/science.1948068. View

Sheng H, Sun H . Synthesis, biology and clinical significance of pentacyclic triterpenes: a multi-target approach to prevention and treatment of metabolic and vascular diseases. Nat Prod Rep. 2011; 28(3):543-93. DOI: 10.1039/c0np00059k. View

10.

Rajic A, Macrides T, Sandeman R, Chandler D, Polya G . Inhibition of serine proteases by anti-inflammatory triterpenoids. Planta Med. 2000; 66(3):206-10. DOI: 10.1055/s-2000-8657. View

11.

Cichewicz R, Kouzi S . Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection. Med Res Rev. 2003; 24(1):90-114. DOI: 10.1002/med.10053. View

12.

Krasutsky P . Birch bark research and development. Nat Prod Rep. 2006; 23(6):919-42. DOI: 10.1039/b606816b. View

13.

Ebrahimzadeh M, Nabavi S, Nabavi S . Antioxidant activities of methanol extract of Sambucus ebulus L. flower. Pak J Biol Sci. 2009; 12(5):447-50. DOI: 10.3923/pjbs.2009.447.450. View

14.

Green L, Wagner D, Glogowski J, Skipper P, Wishnok J, Tannenbaum S . Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem. 1982; 126(1):131-8. DOI: 10.1016/0003-2697(82)90118-x. View

15.

Nishikimi M, Appaji N, Yagi K . The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen. Biochem Biophys Res Commun. 1972; 46(2):849-54. DOI: 10.1016/s0006-291x(72)80218-3. View

16.

Huang D, Ou B, Prior R . The chemistry behind antioxidant capacity assays. J Agric Food Chem. 2005; 53(6):1841-56. DOI: 10.1021/jf030723c. View

17.

Pour B, Latha L, Sasidharan S . Cytotoxicity and oral acute toxicity studies of Lantana camara leaf extract. Molecules. 2011; 16(5):3663-74. PMC: 6263369. DOI: 10.3390/molecules16053663. View

18.

Parthasarathy S, Bin Azizi J, Ramanathan S, Ismail S, Sasidharan S, Said M . Evaluation of antioxidant and antibacterial activities of aqueous, methanolic and alkaloid extracts from Mitragyna speciosa (Rubiaceae family) leaves. Molecules. 2009; 14(10):3964-74. PMC: 6255380. DOI: 10.3390/molecules14103964. View

19.

Hagerman A, Riedl K, Jones G, Sovik K, Ritchard N, Hartzfeld P . High Molecular Weight Plant Polyphenolics (Tannins) as Biological Antioxidants. J Agric Food Chem. 2017; 46(5):1887-1892. DOI: 10.1021/jf970975b. View

20.

Sharma O, Makkar H, Dawra R . A review of the noxious plant Lantana camara. Toxicon. 1988; 26(11):975-87. DOI: 10.1016/0041-0101(88)90196-1. View