Neuropsychological and Neuroimaging Markers in Early Versus Late-onset Alzheimer's Disease

Overview

Journal Am J Alzheimers Dis Other Demen

Publisher Sage Publications

Specialty Neurology

Date 2012 Sep 20

PMID 22990206

Citations 21

Authors

Natalie C Kaiser

Rebecca J Melrose

Collin Liu

David L Sultzer

Elvira Jimenez

Michael Su

Lorena Monserratt

Mario F Mendez

Affiliations

Soon will be listed here.

Abstract

Background: Early-onset Alzheimer's disease (EOAD) has been overshadowed by the more common late-onset AD (LOAD). Yet, the literature indicates EOAD may have less hippocampal-memory presentations and more focal neocortical localization early in the disease.

Objective: To evaluate these proposed differences between these 2 forms of AD and to explore what they inform about differences in AD pathophysiology.

Methods: In all, 21 patients with EOAD and 24 patients with LOAD matched for disease progression and severity were compared on neurocognitive measures and resting state fluorodeoxy-glucose positron-emission tomography (FDG-PET).

Results: Patients with EOAD had worse executive functions with greater hypometabolism in the parietal regions; whereas patients with LOAD had worse confrontation naming and verbal recognition memory with greater hypometabolism in inferior frontotemporal regions.

Conclusions: In addition to highlighting significant differences between EOAD and LOAD, these results reveal dissociation between executive deficits in AD and frontal hypometabolism, suggesting early disturbances of the parietal-frontal network in EOAD.

Citing Articles

Clinical characteristics and biomarker profile in early- and late-onset Alzheimer's disease: the Shanghai Memory Study.

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Molecular neuroimaging in dominantly inherited versus sporadic early-onset Alzheimer's disease.

Iaccarino L, Llibre-Guerra J, McDade E, Edwards L, Gordon B, Benzinger T Brain Commun. 2024; 6(3):fcae159.

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Longitudinal clinical, cognitive and biomarker profiles in dominantly inherited versus sporadic early-onset Alzheimer's disease.

Llibre-Guerra J, Iaccarino L, Coble D, Edwards L, Li Y, McDade E Brain Commun. 2023; 5(6):fcad280.

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The APOE4 effect: structural brain differences in Alzheimer's disease according to the age at symptom onset.

Forno G, Contador J, Perez-Millan A, Guillen N, Falgas N, Sarto J Eur J Neurol. 2022; 30(3):597-605.

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Clinical Manifestations of Early-Onset Dementia With Lewy Bodies Compared With Late-Onset Dementia With Lewy Bodies and Early-Onset Alzheimer Disease.

Sim J, Li H, Hameed S, Ting S JAMA Neurol. 2022; 79(7):702-709.

PMID: 35604656 PMC: 9127709. DOI: 10.1001/jamaneurol.2022.1133.

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