The Origin and Arrhythmogenic Potential of Fibroblasts in Cardiac Disease

Overview

Journal J Cardiovasc Transl Res

Publisher Springer

Specialty Cardiology & Vascular Diseases

Date 2012 Sep 19

PMID 22987310

Citations 21

Authors

Carolina Vasquez

Gregory E Morley

Affiliations

Soon will be listed here.

Abstract

Fibroblasts play a major role in normal cardiac physiology and in the response of the heart to injury and disease. Cardiac electrophysiological research has primarily focused on the mechanisms of remodeling that accompany cardiac disease with an emphasis on myocyte electrophysiology. Recently, there has been increasing interest in the potential role of fibroblasts in cardiac electrophysiology. This review focuses on the arrhythmia mechanisms involving interactions between myocytes and fibroblasts. We also discuss the available evidence supporting the contribution of intracardiac and extracardiac sources to the fibroblast and myofibroblast populations in diseased hearts.

Citing Articles

Epigenetic Regulation of Fibroblasts and Crosstalk between Cardiomyocytes and Non-Myocyte Cells in Cardiac Fibrosis.

Chu L, Xie D, Xu D Biomolecules. 2023; 13(9).

PMID: 37759781 PMC: 10526373. DOI: 10.3390/biom13091382.

An Experimental and Numerical Investigation of Cardiac Tissue-Patch Interrelation.

Basara G, Bahcecioglu G, Ren X, Zorlutuna P J Biomech Eng. 2023; 145(8).

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In silico analysis of the contribution of cardiomyocyte-fibroblast electromechanical interaction to the arrhythmia.

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PMID: 36969594 PMC: 10036780. DOI: 10.3389/fphys.2023.1123609.

Cardiac Cell Patterning on Customized Microelectrode Arrays for Electrophysiological Recordings.

Ji J, Ren X, Zorlutuna P Micromachines (Basel). 2021; 12(11).

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Development of a drug screening system using three-dimensional cardiac tissues containing multiple cell types.

Takeda M, Miyagawa S, Ito E, Harada A, Mochizuki-Oda N, Matsusaki M Sci Rep. 2021; 11(1):5654.

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