The Role of Squamous Cell Carcinoma Antigen As a Prognostic and Predictive Factor in Carcinoma of Uterine Cervix
Overview
Affiliations
Purpose: Although the role of squamous cell carcinoma antigen (SCC-Ag) as a predictive and prognostic factor for uterine cervical cancer has been identified in previous studies, 1) the effective patient group of screening for recurrence with SCC-Ag, 2) the relationship between SCC-Ag and recurrence site, and 3) the relationship between the change of SCC-Ag and treatment outcome or recurrence have not been described.
Materials And Methods: The study included 506 patients with histologically proven uterine cervical cancer between January 1994 and December 2010. We determining the serum SCC-Ag level before treatment and after treatment, and conducted a retrospective review of the patients' records. We evaluated the sensitivity and specificity of SCC-Ag for the detection of tumor recurrence by comparing biochemical recurrence with clinical recurrence.
Results: The pretreatment SCC-Ag level and the proportion of patients over 1.5 ng/mL were higher in poor prognostic patient group. In the univariate and multivariate analysis, pretreatment SCC-Ag showed a statistically significant correlation with tumor size, International Federation of Gynecology and Obstetrics (FIGO) stage, pathology. In patients with biochemical recurrence vs. those without, 5-year DFS and OS were 27.6 vs. 92.7% (p ≤ 0.001) and 53.7 vs. 92.5% (p ≤ 0.001), respectively.
Conclusion: Our study reconfirmed the known function of pretreatment SCC-Ag, but could not confirm the function of biochemical response as a predictive factor for treatment and as a prognostic factor. There was no statistically significant relationship between SCC-Ag level and recurrence site. We confirmed the role of SCC-Ag as a follow-up tool for recurrence of disease and which patient groups SCC-Ag was more useful for.
Reginacova K, Pospisilova E, Kubecova M, Svobodova P, Bobek V, Kolostova K Am J Cancer Res. 2024; 14(7):3614-3625.
PMID: 39113856 PMC: 11301293. DOI: 10.62347/QIXJ7103.
Beaussire-Trouvay L, Duhamel O, Perdrix A, Leveque E, Vion R, Rovelet-Lecrux A Front Oncol. 2024; 14:1382008.
PMID: 39040450 PMC: 11260666. DOI: 10.3389/fonc.2024.1382008.
Ma Y, Zhao X, Chen X Front Oncol. 2024; 14:1301900.
PMID: 38634056 PMC: 11021703. DOI: 10.3389/fonc.2024.1301900.
Fatty acid metabolism: A new therapeutic target for cervical cancer.
Ping P, Li J, Lei H, Xu X Front Oncol. 2023; 13:1111778.
PMID: 37056351 PMC: 10088509. DOI: 10.3389/fonc.2023.1111778.
Chen W, Xiu S, Xie X, Guo H, Xu Y, Bai P Radiat Oncol. 2022; 17(1):6.
PMID: 35012582 PMC: 8751300. DOI: 10.1186/s13014-021-01978-0.