Complementary Roles of Mitochondrial Respiration and ROS Signaling on Cellular Aging and Longevity

Overview

Journal Aging (Albany NY)

Specialty Geriatrics

Date 2012 Sep 18

PMID 22983483

Citations 10

Authors

Antoni Barrientos

Affiliations

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Abstract

Although it is widely accepted that mitochondria play fundamental roles in the mechanisms of cellular and organismal aging and lifespan extension, some open questions remain concerning the requirements for aerobic energy production and the effect of the potentially hazardous reactive oxygen species (ROS) byproducts as well as their interplay with nutrition and caloric intake.

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