Signal Transduction Via the T Cell Antigen Receptor in Naïve and Effector/memory T Cells

Overview

Journal Int J Biochem Cell Biol

Publisher Elsevier

Specialties Biochemistry
Cell Biology

Date 2012 Sep 18

PMID 22981631

Citations 19

Authors

Arun Kannan

Weishan Huang

Fei Huang

Avery August

Affiliations

Soon will be listed here.

Abstract

T cells play an indispensable role in immune defense against infectious agents, but can also be pathogenic. These T cells develop in the thymus, are exported into the periphery as naïve cells and participate in immune responses. Upon recognition of antigen, they are activated and differentiate into effector and memory T cells. While effector T cells carry out the function of the immune response, memory T cells can last up to the life time of the individual, and are activated by subsequent antigenic exposure. Throughout this life cycle, the T cell uses the same receptor for antigen, the T cell Receptor, a complex multi-subunit receptor. Recognition of antigen presented by peptide/MHC complexes on antigen presenting cells unleashes signaling pathways that control T cell activation at each stage. In this review, we discuss the signals regulated by the T cell receptor in naïve and effector/memory T cells.

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References

Babich A, Li S, OConnor R, Milone M, Freedman B, Burkhardt J . F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activation. J Cell Biol. 2012; 197(6):775-87. PMC: 3373411. DOI: 10.1083/jcb.201201018. View

Huang Y, Grasis J, Miller A, Xu R, Soonthornvacharin S, Andreotti A . Positive regulation of Itk PH domain function by soluble IP4. Science. 2007; 316(5826):886-9. DOI: 10.1126/science.1138684. View

Chung K . p38 mitogen-activated protein kinase pathways in asthma and COPD. Chest. 2011; 139(6):1470-1479. DOI: 10.1378/chest.10-1914. View

Alarcon B, Mestre D, Martinez-Martin N . The immunological synapse: a cause or consequence of T-cell receptor triggering?. Immunology. 2011; 133(4):420-5. PMC: 3143353. DOI: 10.1111/j.1365-2567.2011.03458.x. View

Saito K, Tolias K, Saci A, Koon H, Humphries L, Scharenberg A . BTK regulates PtdIns-4,5-P2 synthesis: importance for calcium signaling and PI3K activity. Immunity. 2003; 19(5):669-78. DOI: 10.1016/s1074-7613(03)00297-8. View

Isaacs J . T cell immunomodulation--the Holy Grail of therapeutic tolerance. Curr Opin Pharmacol. 2007; 7(4):418-25. DOI: 10.1016/j.coph.2007.05.001. View

Trujillo J . MEK inhibitors: a patent review 2008 - 2010. Expert Opin Ther Pat. 2011; 21(7):1045-69. DOI: 10.1517/13543776.2011.577068. View

Rhee I, Veillette A . Protein tyrosine phosphatases in lymphocyte activation and autoimmunity. Nat Immunol. 2012; 13(5):439-47. DOI: 10.1038/ni.2246. View

Gibson S, August A, Branch D, DuPont B, Mills G . Functional LCK Is required for optimal CD28-mediated activation of the TEC family tyrosine kinase EMT/ITK. J Biol Chem. 1996; 271(12):7079-83. DOI: 10.1074/jbc.271.12.7079. View

10.

Hirabayashi A, Mukaiyama H, Kobayashi H, Shiohara H, Nakayama S, Ozawa M . Structure-activity relationship studies of 5-benzylaminoimidazo[1,2-c]pyrimidine-8-carboxamide derivatives as potent, highly selective ZAP-70 kinase inhibitors. Bioorg Med Chem. 2008; 17(1):284-94. DOI: 10.1016/j.bmc.2008.10.070. View

11.

Fayard E, Moncayo G, Hemmings B, Hollander G . Phosphatidylinositol 3-kinase signaling in thymocytes: the need for stringent control. Sci Signal. 2010; 3(135):re5. DOI: 10.1126/scisignal.3135re5. View

12.

von Boehmer H, Melchers F . Checkpoints in lymphocyte development and autoimmune disease. Nat Immunol. 2009; 11(1):14-20. DOI: 10.1038/ni.1794. View

13.

Williams M, Ravkov E, Bevan M . Rapid culling of the CD4+ T cell repertoire in the transition from effector to memory. Immunity. 2008; 28(4):533-45. PMC: 2391296. DOI: 10.1016/j.immuni.2008.02.014. View

14.

Bachmann M, Gallimore A, Linkert S, Cerundolo V, Lanzavecchia A, Kopf M . Developmental regulation of Lck targeting to the CD8 coreceptor controls signaling in naive and memory T cells. J Exp Med. 1999; 189(10):1521-30. PMC: 2193636. DOI: 10.1084/jem.189.10.1521. View

15.

Wucherpfennig K, Gagnon E, Call M, Huseby E, Call M . Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling. Cold Spring Harb Perspect Biol. 2010; 2(4):a005140. PMC: 2845206. DOI: 10.1101/cshperspect.a005140. View

16.

Brembilla N, Weber J, Rimoldi D, Pradervand S, Schutz F, Pantaleo G . c-Cbl expression levels regulate the functional responses of human central and effector memory CD4 T cells. Blood. 2008; 112(3):652-60. PMC: 2481558. DOI: 10.1182/blood-2008-01-134486. View

17.

Russell R, Fang C, Guan K . An emerging role for TOR signaling in mammalian tissue and stem cell physiology. Development. 2011; 138(16):3343-56. PMC: 3143559. DOI: 10.1242/dev.058230. View

18.

Robins H, Campregher P, Srivastava S, Wacher A, Turtle C, Kahsai O . Comprehensive assessment of T-cell receptor beta-chain diversity in alphabeta T cells. Blood. 2009; 114(19):4099-107. PMC: 2774550. DOI: 10.1182/blood-2009-04-217604. View

19.

Araki K, Turner A, Shaffer V, Gangappa S, Keller S, Bachmann M . mTOR regulates memory CD8 T-cell differentiation. Nature. 2009; 460(7251):108-12. PMC: 2710807. DOI: 10.1038/nature08155. View

20.

Song J, Lei F, Xiong X, Haque R . Intracellular signals of T cell costimulation. Cell Mol Immunol. 2008; 5(4):239-47. PMC: 4651295. DOI: 10.1038/cmi.2008.30. View