Miglustat-induced Intestinal Carbohydrate Malabsorption is Due to the Inhibition of α-glucosidases, but Not β-galactosidases

Overview

Journal J Inherit Metab Dis

Publisher Wiley

Date 2012 Sep 15

PMID 22976762

Citations 16

Authors

Mahdi Amiri

Hassan Y Naim

Affiliations

Soon will be listed here.

Abstract

Miglustat is an oral medication that has approved indication for type I Gaucher disease and Niemann pick disease type C. Usually treatment with Miglustat is associated with occurrence of gastrointestinal side effects similar to carbohydrate maldigestion symptoms. Here, we studied the direct influence of Miglustat on the enzymatic function of the major disaccharidases of the intestinal epithelium. Our findings show that an immediate effect of Miglustat is its interference with carbohydrate digestion in the intestinal lumen via reversible inhibition of disaccharidases that cleave α-glycosidically linked carbohydrates. Higher non physiological concentrations of Miglustat can partly affect lactase activity. We further show that the inhibition of the disaccharidases function by Miglustat is mainly competitive and does not occur via alteration of the enzyme folding.

Citing Articles

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