Genetic Visualization of Notch Signaling in Mammalian Neurogenesis

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2012 Sep 14

PMID 22971775

Citations 27

Authors

Itaru Imayoshi

Hiromi Shimojo

Masayuki Sakamoto

Toshiyuki Ohtsuka

Ryoichiro Kageyama

Affiliations

Soon will be listed here.

Abstract

Notch signaling plays crucial roles in fate determination and the differentiation of neural stem cells in embryonic and adult brains. It is now clear that the notch pathway is under more complex and dynamic regulation than previously thought. To understand the functional details of notch signaling more precisely, it is important to reveal when, where, and how notch signaling is dynamically communicated between cells, for which the visualization of notch signaling is essential. In this review, we introduce recent technical advances in the visualization of notch signaling during neural development and in the adult brain, and we discuss the physiological significance of dynamic regulation of notch signaling.

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