Antioxidant and Anti-Inflammatory Properties of Longan (Dimocarpus Longan Lour.) Pericarp

Overview

Journal Evid Based Complement Alternat Med

Specialty Rehabilitation Medicine

Date 2012 Sep 12

PMID 22966244

Citations 12

Authors

Guan-Jhong Huang

Bor-Sen Wang

Wei-Chao Lin

Shyh-Shyun Huang

Chao-Ying Lee

Ming-Tsung Yen

Ming-Hsing Huang

Affiliations

Soon will be listed here.

Abstract

This study examined the antioxidant and anti-inflammatory activities of the water extract of longan pericarp (WLP). The results showed that WLP exhibited radical scavenging, reducing activity and liposome protection activity. In addition, WLP also inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) production in macrophages. Further, administration of WLP, in the range of 100-400 mg/kg, showed a concentration-dependent inhibition on paw edema development following carrageenan (Carr) treatment in mice. The anti-inflammatory effects of WLP may be related to NO and tumor necrosis factor (TNF-α) suppression and associated with the increase in the activities of antioxidant enzymes, including catalase, superoxide dismutase, and glutathione peroxidase. Overall, the results showed that WLP might serve as a natural antioxidant and inflammatory inhibitor.

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