Angiopoietin-like Protein 2 and Risk of Type 2 Diabetes in a General Japanese Population: the Hisayama Study

Overview

Journal Diabetes Care

Specialty Endocrinology

Date 2012 Sep 12

PMID 22966088

Citations 39

Authors

Yasufumi Doi

Toshiharu Ninomiya

Yoichiro Hirakawa

Otowa Takahashi

Naoko Mukai

Jun Hata

Masanori Iwase

Takanari Kitazono

Yuichi Oike

Yutaka Kiyohara

Affiliations

Soon will be listed here.

Abstract

Objective: To examine, for the first time, the association between a novel inflammatory cytokine, angiopoietin-like protein (ANGPTL) 2, and the development of type 2 diabetes (T2DM).

Research Design And Methods: A total of 2,164 community-dwelling Japanese individuals aged 40 to 79 years without diabetes were followed up for 7 years. Serum ANGPTL2 levels were divided into quartile categories at baseline: <2.15, 2.16-2.71, 2.72-3.40, and ≥3.41 ng/mL. During follow-up, 221 participants developed T2DM.

Results: In multivariate analyses, after adjusting for comprehensive risk factors and high-sensitivity C-reactive protein (hs-CRP) levels, the risk of developing T2DM was significantly higher in the highest ANGPTL2 quartile than in the lowest quartile (hazard ratio, 1.80; 95% CI, 1.14-2.85; P = 0.01).

Conclusions: Elevated serum ANGPTL2 levels were positively associated with the development of T2DM in a general population, independent of other risk factors including hs-CRP levels.

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