Clinical and Virologic Course of Herpes Simplex Genitalis

Overview

Journal West J Med

Specialty General Medicine

Date 1979 May 1

PMID 229646

Citations 7

Authors

Z A Brown

E R Kern

S L Spruance

J C Overall Jr

Affiliations

Soon will be listed here.

Abstract

The clinical and virologic course of herpes simplex genitalis in women and men was examined in order to identify measurements useful in antiviral trials. Factors influencing the clinical course included initial disease versus recurrent disease, wet-skin versus dry-skin lesions, female versus male sex. Women with initial genital herpes had higher mean peak lesion virus titers than those with recurrent disease (10(4.5) pfu compared with 10(2.5) pfu) and excreted virus longer (13 to 15 days compared with 6 to 8 days). Men with recurrent lesions had higher mean peak virus titers than women (10(4.0) pfu compared with 10(2.5) pfu), but the duration of virus excretion was shorter (three to four days compared with six to eight days). There was pronounced variation in the clinical and virologic course of recurrent lesions among different patients and even within the same patient. These observations indicate several difficulties that must be considered in conducting careful antiviral trials in patients with herpes simplex genitalis.

Citing Articles

Genital herpetic infection: a family practice perspective.

Lawee D Can Fam Physician. 2011; 28:1839-48.

PMID: 21286567 PMC: 2306699.

Herpes genitalis in patients attending a clinic for sexually transmitted diseases.

Lawee D, Gutman M, Hrytzay M, McLachlin J Can Fam Physician. 2011; 29:258-64.

PMID: 21283317 PMC: 2153772.

Single-day famciclovir for the treatment of genital herpes: follow-up results of time to next recurrence and assessment of antiviral resistance.

Bodsworth N, Fife K, Koltun W, Tyring S, Abudalu M, Prichard M Curr Med Res Opin. 2009; 25(2):483-7.

PMID: 19192993 PMC: 3773849. DOI: 10.1185/03007990802664678.

Single-day therapy: an expert opinion on a recent development for the episodic treatment of recurrent genital herpes.

Tyring S, Richwald G, Hamed K Arch Gynecol Obstet. 2006; 275(1):1-3.

PMID: 16957911 PMC: 1705528. DOI: 10.1007/s00404-006-0234-z.

Relationship of antibody to outcome in neonatal herpes simplex virus infections.

Yeager A, Arvin A, Urbani L, Kemp 3rd J Infect Immun. 1980; 29(2):532-8.

PMID: 7216423 PMC: 551151. DOI: 10.1128/iai.29.2.532-538.1980.

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