A Cultured Affair: HSV Latency and Reactivation in Neurons

Overview

Journal Trends Microbiol

Date 2012 Sep 12

PMID 22963857

Citations 94

Authors

Angus C Wilson

Ian Mohr

Affiliations

Soon will be listed here.

Abstract

After replicating in surface epithelia, herpes simplex virus type-1 (HSV-1) enters the axonal terminals of peripheral neurons. The viral genome translocates to the nucleus, where it establishes a specialized infection known as latency, re-emerging periodically to seed new infections. Studies using cultured neuron models that faithfully recapitulate the molecular hallmarks of latency and reactivation defined in live animal models have provided fresh insight into the control of latency and connections to neuronal physiology. With this comes a growing appreciation for how the life cycles of HSV-1 and other herpesviruses are governed by key host pathways controlling metabolic homeostasis and cell identity.

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