Migraine and Genetic Polymorphisms: an Overview

Overview

Journal Open Neurol J

Publisher Bentham Open

Specialty Neurology

Date 2012 Sep 11

PMID 22962564

Citations 6

Authors

Vincenzo Pizza

Anella Agresta

Antonio Agresta

Eros Lamaida

Norman Lamaida

Francesco Infante

Anna Capasso

Affiliations

Soon will be listed here.

Abstract

The relationship between genetic polymorphisms and migraine as a cause of an increased risk of thrombotic disorders development is still debated In this respect, factor V Leiden, factor V (H1299R), prothrombin G20210A, factor XIII (V34L), β-fibrinogen, MTHFR (C677T), MTHFR (A1298C), APO E, PAI-1, HPA-1 and ACE I/D seem to play a determinant role in vascular diseases related to migraine. The present review analyzes both the incidence of the above genetic vascular mutations in migraineurs and the most re-cent developments related to genetic polymorphisms and migraine.

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